Results 161 to 170 of about 11,407 (198)

High pretreatment peripheral blood T-cell receptor clonality as a predictor of prolonged response in immune thrombocytopenia. [PDF]

Br J Haematol
Schmidt-Barbo P, Schultheiss C, Jauch AJ, Simnica D, Silling G, Hänel M, Chromik J, Stauch T, Trautmann-Grill K, Repp R, Schulte C, Fleischmann B, Welslau M, Stauch M, Quiering C, Richter F, Tesanovic T, Jahn S, Holbro A, Passweg JR, Matzdorff A, Rummel M, Meyer O, Nimmerjahn F, Binder M.   +24 more
europepmc   +1 more source

Analysis of CDR3 region diversity with different lengths in bovine immunoglobulin heavy chain genes. [PDF]

Front Immunol
Zhao H, Tang X, Zhang Y, Wu M.
europepmc   +1 more source

Somatic hypermutation of immunoglobulin and non–immunoglobulin genes [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2001
Somatic hypermutation (SHM) of immunoglobulin (Ig) genes is a highly specific mechanism restricted to B lymphocytes during only a few cell generations. Data presented here suggest that transcription of the target genes is required, but not sufficient for SHM. Presumably, cis –acting elements,
Ursula Storb, U Storb
exaly   +3 more sources

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Immunoglobulin Somatic Hypermutation

Annual Review of Genetics, 2007
The immunoglobulin (Ig) repertoire achieves functional diversification through several somatic alterations of the Ig locus. One of these processes, somatic hypermutation (SHM), deposits point mutations into the variable region of the Ig gene to generate higher-affinity variants.
Grace, Teng, F Nina, Papavasiliou
openaire   +2 more sources

The molecular basis of somatic hypermutation of immunoglobulin genes

Current Opinion in Immunology, 1996
Somatic hypermutation amplifies the variable region repertoire of immunoglobulin genes. Recent experimental evidence has thrown light on various molecular models of somatic hypermutation. A link between somatic hypermutation and transcription coupled DNA repair is shaping up.
Ursula Storb, U Storb
exaly   +3 more sources

SOMATIC HYPERMUTATION OF IMMUNOGLOBULIN GENES

Annual Review of Immunology, 1996
▪ Abstract  The relationship between somatic hypermutation and affinity maturation in the mouse is delineated. Recent work on the anatomical and cellular site of this process is surveyed. The molecular characteristics of somatic hypermutation are described in terms of the region mutated and the distinctive patterns of nucleotide changes that are ...
S D, Wagner, M S, Neuberger
openaire   +2 more sources

By‐products of immunoglobulin somatic hypermutation

Genes, Chromosomes and Cancer, 2003
AbstractThe antigen receptor loci are the only loci in humans to undergo programmed somatic gene modification. Although aberrant V(D)J integration and class switch recombination can both give rise to chromosomal translocations, a role for somatic hypermutation in such genomic rearrangements has been suggested but is less clearly established.
Mats, Bemark, Michael S, Neuberger
openaire   +2 more sources

Immunoglobulin transgenes as targets for somatic hypermutation

The International Journal of Developmental Biology, 1998
This review describes studies on somatic hypermutation of immunoglobulin genes that were started in the mid-80s in collaboration with Ralph Brinster. Almost all of the experiments were carried out using Ig transgenes as targets for the somatic mutation mechanism.
U, Storb, A, Peters, E, Klotz, N, Kim, H M, Shen, J, Hackett, B, Rogerson, R, O'Brien, T E, Martin   +8 more
openaire   +2 more sources

Somatic hypermutation of immunoglobulin genes in Rad18 knockout mice

DNA Repair, 2017
Somatic hypermutation (SHM) of immunoglobulin (Ig) genes is triggered by the activity of activation-induced cytidine deaminase (AID). AID induces DNA lesions in variable regions of Ig genes, and error-prone DNA repair mechanisms initiated in response to these lesions introduce the mutations that characterize SHM.
Takeyuki, Shimizu, Satoshi, Tateishi, Yuki, Tanoue, Takachika, Azuma, Haruo, Ohmori   +4 more
openaire   +2 more sources

Somatic hypermutation of immunoglobulin genes is independent of the Bloom's syndrome DNA helicase

Clinical and Experimental Immunology, 1998
SUMMARYImmunoglobulin gene somatic mutation leads to antibody affinity maturation through the introduction of multiple point mutations in the antigen binding site. No genes have as yet been identified that participate in this process. Bloom's syndrome (BS) is a chromosomal breakage disorder with a mutator phenotype. Most affected individuals exhibit an
Nancy S Green, German J, J German
exaly   +4 more sources