Results 171 to 180 of about 11,407 (198)
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Somatic hypermutation of an immunoglobulin transgene in K transgenic mice
Nature, 1987Initial studies of somatically acquired mutations in immunoglobulin V regions from hybridomas and myelomas that are not derived from joining aberrations, suggested a controlled and specific hypermutation process, because spontaneous mutation rates observed for other genes are extremely low.
R L, O'Brien, R L, Brinster, U, Storb
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Somatic Hypermutation of Immunoglobulin Genes is Linked to Transcription
1998Immunoglobulin (Ig) genes are rearranged in pre-B cells. Pre-B cells that express Ig heavy (H) and light (L) chain genes whose V(D)J recombination results in a functional reading frame mature into B cells that exit the bone marrow. The V(D)J recombination process creates a large repertoire of different variable regions from a restricted pool of ...
U, Storb +7 more
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Characteristics of Somatic Hypermutation of Human Immunoglobulin Genes
1998Affinity maturation of antibodies after immunization is a result of hypermutation of the variable region of immunoglobulin genes and an antigen selection process that preserves those B lymphocytes with mutated surface immunoglobulin (Ig) expressing an increased affinity for the immunogen (French et al.
R A, Insel, W S, Varade
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Somatic hypermutation of an immunoglobulin mu heavy chain transgene. [PDF]
Journal of Experimental Medicine, 1993 We have analyzed somatic hypermutation of an immunoglobulin (Ig) heavy chain transgene. Hybridomas expressing the transgene were produced from immunized transgenic mice and transgene copies were sequenced to assay for mutation. In two IgM-producing hybridomas, as well as in several IgG-producing hybridomas, mutations were found in the VDJ region of the
J, Sohn +4 more
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Somatic Hypermutation of Immunoglobulin Genes
1998The first convincing evidence for somatic mutation of Ig genes was a study of mouse λ genes carried out by Weigert and collaborators in the early 7os.1 Comparing the amino acid sequences of λ light chain variable (V) regions in nine mouse myelomas, they found that six were identical, and three had one, two, or three amino acid changes.
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Somatic hypermutation of immunoglobulin κ transgenes: Association of mutability with demethylation
Immunology & Cell Biology, 2001Following antigen encounter, immunoglobulin genes are diversified by somatic hypermutation. The mechanism by which this mutational process preferentially targets immunoglobulin genes is not known, but is likely linked to transcription. However, transcription is not sufficient to ensure mutability.
C J, Jolly, M S, Neuberger
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Enhanced Evolvability in Immunoglobulin V Genes Under Somatic Hypermutation
Journal of Molecular Evolution, 1999Darwinian theory requires that mutations be produced in a nonanticipatory manner; it is nonetheless consistent to suggest that mutations that have repeatedly led to nonviable phenotypes would be introduced less frequently than others-if under appropriate genetic control.
L G, Cowell +4 more
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Dual enigma of somatic hypermutation of immunoglobulin variable genes: targeting and mechanism
Immunological Reviews, 1998Summary: The immunoglobulin loci are uniquely unstable regions of the genome which undergo as much mutation and selection in a matter of days as a species can undergo in generations of evolution. We have studied the mutational pattern and targeting of this manual hypermutation process over the past 16 years.
D B, Winter, P J, Gearhart
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Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota
Nature, 2002Somatic hypermutation of immunoglobulin genes is a unique, targeted, adaptive process. While B cells are engaged in germinal centres in T-dependent responses, single base substitutions are introduced in the expressed Vh/Vl genes to allow the selection of mutants with a higher affinity for the immunizing antigen.
Ahmad, Faili +5 more
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Mechanisms of immunoglobulin somatic hypermutation during retroviral infection
2019A potential HIV-1 vaccine should stimulate a broadly neutralizing antibody (bNAb) response, which overcomes HIV-1 mutational escape to typical NAb responses that develop by covering a wide variety of HIV-1 strains. bNAbs have been shown to both be highly mutated as well as contain essential mutations in framework regions (FWRs) of the immunoglobulin ...
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