Results 201 to 210 of about 280,773 (255)
Somatic hypermutation and germline evolution of immunoglobulin variable genes
, 1994 Harald S. Rothenfluh
openalex +1 more source
(GC-arc11) Invariant-governed accessibility constrains somatic hypermutation and immune fate
JAMES SUTTON
openalex +1 more source
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Molecular mechanisms of antibody somatic hypermutation.
Annual Review of Biochemistry, 2007Functional antibody genes are assembled by V-D-J joining and then diversified by somatic hypermutation. This hypermutation results from stepwise incorporation of single nucleotide substitutions into the V gene, underpinning much of antibody diversity and affinity maturation.
J. D. Di Noia, M. Neuberger
semanticscholar +3 more sources
Current Opinion in Immunology, 1995
For the generation of secondary response antibodies, immunoglobulin genes are subjected to hypermutation. Cells expressing antibodies with higher affinity are then selected by antigen. Recent clues to the mechanism of hypermutation come from experiments using transgenic mice enabling analysis of the controlling cis-acting elements and the intrinsic ...
M S, Neuberger, C, Milstein
openaire +2 more sources
For the generation of secondary response antibodies, immunoglobulin genes are subjected to hypermutation. Cells expressing antibodies with higher affinity are then selected by antigen. Recent clues to the mechanism of hypermutation come from experiments using transgenic mice enabling analysis of the controlling cis-acting elements and the intrinsic ...
M S, Neuberger, C, Milstein
openaire +2 more sources
Immunoglobulin Somatic Hypermutation
Annual Review of Genetics, 2007The immunoglobulin (Ig) repertoire achieves functional diversification through several somatic alterations of the Ig locus. One of these processes, somatic hypermutation (SHM), deposits point mutations into the variable region of the Ig gene to generate higher-affinity variants.
Grace, Teng, F Nina, Papavasiliou
openaire +2 more sources
Targeting of somatic hypermutation
Nature Reviews Immunology, 2006Somatic hypermutation (SHM) introduces mutations in the variable region of immunoglobulin genes at a rate of approximately 10(-3) mutations per base pair per cell division, which is 10(6)-fold higher than the spontaneous mutation rate in somatic cells. To ensure genomic integrity, SHM needs to be targeted specifically to immunoglobulin genes.
Valerie H, Odegard, David G, Schatz
openaire +2 more sources
Somatic hypermutation: subverted DNA repair
Current Opinion in Immunology, 2006Somatic hypermutation generates high-affinity antibodies of different isotypes that efficiently protect us against a plethora of pathogens. Recent analyses of the types of mutations produced in gene-deficient mice have indicated how DNA repair proteins are drawn into the pathway.
Stella A, Martomo, Patricia J, Gearhart
openaire +2 more sources
The targeting of somatic hypermutation
Seminars in Immunology, 1996Somatic hypermutation does not occur randomly within immunoglobulin V genes but, rather, is preferentially targeted to certain nucleotide positions (hot spots) and away from others (cold spots). Cold spots often coincide with residues essential for V gene folding.
C J, Jolly +5 more
openaire +2 more sources
The Biochemistry of Somatic Hypermutation
Annual Review of Immunology, 2008Affinity maturation of the humoral response is mediated by somatic hypermutation of the immunoglobulin (Ig) genes and selection of higher-affinity B cell clones. Activation-induced cytidine deaminase (AID) is the first of a complex series of proteins that introduce these point mutations into variable regions of the Ig genes.
Jonathan U, Peled +6 more
openaire +2 more sources