Results 181 to 190 of about 20,554 (213)
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Somatic hypermutation: subverted DNA repair
Current Opinion in Immunology, 2006Somatic hypermutation generates high-affinity antibodies of different isotypes that efficiently protect us against a plethora of pathogens. Recent analyses of the types of mutations produced in gene-deficient mice have indicated how DNA repair proteins are drawn into the pathway.
Stella A, Martomo, Patricia J, Gearhart
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Tuning Somatic Hypermutation by Transcription
1999The dependence of somatic hypermutation on transcription was studied in three mutant immunoglobulin heavy chain (IgH) insertion mice in which a targeted non-functional VHB1-8 passenger transgene was either placed under the transcriptional control of a truncated DQ52 promoter (p delta), its own RNA polymerase II dependent IgH promoter (pII) or a RNA ...
H, Jacobs +3 more
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Retroviral vectors to monitor somatic hypermutation
Journal of Immunological Methods, 2005The recent expansion of studies on hypermutation may benefit from a fast and uncomplicated way to measure mutation rates. In this paper we compare different retroviral vector designs for monitoring hypermutation in vivo. Retroviral vectors combine a high transduction rate with integration at random sites within the host cell genome, thus equalizing ...
Maik, Klasen +3 more
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Somatic Hypermutation: A Mutational Panacea
2004Publisher Summary This chapter discusses activation-induced deaminase (AID), which was discovered using a subtractive hybridization screen for genes activated on induction of class switch recombination (CSR). AID expression is restricted to activated B cells and is required for somatic hypermutation (SHM) in mice.
Brigette, Tippin +3 more
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Molecular Mechanisms of Antibody Somatic Hypermutation
Annual Review of Biochemistry, 2007Functional antibody genes are assembled by V-D-J joining and then diversified by somatic hypermutation. This hypermutation results from stepwise incorporation of single nucleotide substitutions into the V gene, underpinning much of antibody diversity and affinity maturation.
Javier M, Di Noia, Michael S, Neuberger
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Somatic hypermutation in antoimmune thyroid disease
Immunological Reviews, 1998Summary: Autoimmune thyroid disease is one of the most common autoimmune diseases. There is typically patient antibody (Ab) reactivity to one or more of the antigens thyroglobulin (Tg), thyroid peroxidase (TPO) and the thyroid stimulating hormone receptor (TSFlr). With the advent of combinatorial library technology, there has been an enormous increase
R, McIntosh, P, Watson, A, Weetman
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Immunoglobulin transgenes as targets for somatic hypermutation
The International Journal of Developmental Biology, 1998This review describes studies on somatic hypermutation of immunoglobulin genes that were started in the mid-80s in collaboration with Ralph Brinster. Almost all of the experiments were carried out using Ig transgenes as targets for the somatic mutation mechanism.
U, Storb +8 more
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Mesoscale DNA feature in antibody-coding sequence facilitates somatic hypermutation
Cell, 2023Pengfei Dai, Fei-Long Meng
exaly