Results 71 to 80 of about 280,773 (255)

Cell Cycle Regulates Nuclear Stability of AID and Determines the Cellular Response to AID. [PDF]

PLoS Genetics, 2015
AID (Activation Induced Deaminase) deaminates cytosines in DNA to initiate immunoglobulin gene diversification and to reprogram CpG methylation in early development.
Quy Le, Nancy Maizels
doaj   +1 more source

High pretreatment peripheral blood T‐cell receptor clonality as a predictor of prolonged response in immune thrombocytopenia to the British Journal of Haematology

British Journal of Haematology, EarlyView.
Left panel: Scheme of the XPAG‐immune thrombocytopenia trial. The dexamethasone (DEX) arm consisted of DEX 40 mg/day for days 1–4 for one to three cycles every 28 days to a maximum of 12 weeks, cycles 2 + 3 were optional. Patients randomised to eltrombopag (ETB) + DEX received eltrombopag in combination with a short course of high‐dose DEX beginning on
Paul Schmidt‐Barbo, Christoph Schultheiss, Annaïse J. Jauch, Donjetë Simnica, Gerda Silling, Mathias Hänel, Jörg Chromik, Thomas Stauch, Karolin Trautmann‐Grill, Roland Repp, Clemens Schulte, Bastian Fleischmann, Manfred Welslau, Martina Stauch, Claudia Quiering, Frank Richter, Tamara Tesanovic, Sabine Jahn, Andreas Holbro, Jakob R. Passweg, Axel Matzdorff, Mathias Rummel, Oliver Meyer, Falk Nimmerjahn, Mascha Binder   +24 more
wiley   +1 more source

High-throughput immune repertoire analysis with IGoR

Nature Communications, 2018
B and T cell receptor diversity can be studied by high-throughput immune receptor sequencing. Here, the authors develop a software tool, IGoR, that calculates the likelihoods of potential V(D)J recombination and somatic hypermutation scenarios from raw ...
Quentin Marcou, Thierry Mora, Aleksandra M. Walczak   +2 more
doaj   +1 more source

The somatic POLE P286R mutation defines a unique subclass of colorectal cancer featuring hypermutation, representing a potential genomic biomarker for immunotherapy

OncoTarget, 2016
Early-onset colorectal cancers (EOCRCs) may have biological or genomic features distinct from late-onset CRCs (LOCRCs). Previous studies have mostly focused on the germline predisposition conditions of EOCRCs, but we hypothesized that EOCRCs may have ...
Sung‐Min Ahn, A. A. Ansari, Jihun Kim, Deokhoon Kim, S. Chun, Jiyun Kim, Tae Won Kim, I. Park, C. Yu, S. Jang   +9 more
semanticscholar   +1 more source

Refining Tumor Mutational Burden as a Predictive Biomarker for Pembrolizumab: A Real‐World Analysis in Japanese Patients

Cancer Science, EarlyView.
In this study, we investigated the predictive value of tumor mutational burden (TMB) for assessing the efficacy of pembrolizumab in a Japanese cohort. We analyzed real‐world data from 63,952 patients registered in the C‐CAT database who underwent comprehensive genomic profiling, and evaluated the therapeutic efficacy of pembrolizumab in 1899 of these ...
Tomoyo Yasuda, Mio Yumura, Azusa Hamasaki, Tongyi Fei, Takashi Kubo, Hitoshi Ichikawa, Takashi Kohno, Kuniko Sunami   +7 more
wiley   +1 more source

Immunoglobulin gene loci structure and diversity of raccoon dog (Nyctereutes procyonoides)

BMC Genomics
In this study, we analyzed the loci structure of raccoon dog genes using a comparative genomics approach. We investigated the mechanism of expression diversity and its preference using the Next-generation sequencing.
Xiaohua Yi, Yanbo Qiu, Xiaoqin Tang, Puhang Xie, Chao Xu, Xiuzhu Sun   +5 more
doaj   +1 more source

Histone Modifications Associated with Somatic Hypermutation [PDF]

Immunity, 2005
A number of modified histones, including acetylated H3 and H4 and phosphorylated H2AX (gammaH2AX), are associated with V(D)J recombination and class switch recombination (CSR). In contrast, little is known concerning the chromatin modifications associated with somatic hypermutation (SHM) in vivo.
Odegard, Valerie H., Kim, Sean T., Anderson, Shannon M., Shlomchik, Mark J., Schatz, David G.   +4 more
openaire   +2 more sources

Next‐generation sequencing‐based IG clonality analysis to discriminate reactive infiltrates from minimal lymphoma involvement in paired lymphoma and bone marrow biopsies; a EuroClonality‐NGS Working Group study

Histopathology, EarlyView.
Next‐generation sequencing (NGS) immunoglobulin clonality analysis can help resolve ambiguous bone marrow staging biopsies for B‐cell lymphoma. In this study, paired analysis of the primary lymphoma and bone marrow helped to detect lymphoma involvement in cases with inconclusive morphology and immunohistochemistry, making it a valuable tool for ...
Michiel van den Brand, Meilinde Leenders, Jos Rijntjes, Jeroen A.C.W. Luijks, Anton W. Langerak, Konnie M. Hebeda, Patricia J.T.A. Groenen   +6 more
wiley   +1 more source

Continuous targeted hypermutation with a tunable mutation window

Nature Communications
Targeted in vivo hypermutation drives rapid sequence diversification within specific DNA regions of living cells, enabling continuous evolution of biomolecules for enhanced functionality.
Chanwoo Lee, Seokhee Kim
doaj   +1 more source

Accurate immune repertoire sequencing reveals malaria infection driven antibody lineage diversification in young children

Nature Communications, 2017
Somatic hypermutation of antibodies can occur in infants but are difficult to track. Here the authors present a new method called MIDCIRS for deep quantitative repertoire sequencing with few cells, and show infants as young as 3 months can expand ...
Ben S. Wendel, Chenfeng He, Mingjuan Qu, Di Wu, Stefany M. Hernandez, Ke-Yue Ma, Eugene W. Liu, Jun Xiao, Peter D. Crompton, Susan K. Pierce, Pengyu Ren, Keke Chen, Ning Jiang   +12 more
doaj   +1 more source