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Sonic hedgehog signaling in craniofacial development
Differentiation, 2023Mutations in SHH and several other genes encoding components of the Hedgehog signaling pathway have been associated with holoprosencephaly syndromes, with craniofacial anomalies ranging in severity from cyclopia to facial cleft to midfacial and mandibular hypoplasia.
Jingyue Xu +3 more
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Life, death and Sonic hedgehog
BioEssays, 2000The secreted glycoprotein Sonic hedgehog (SHH), a vertebrate homologue of the Drosophila segment polarity gene Hedgehog, is essential for the development of diverse tissues during embryogenesis. Studies of SHH function during neural tube and somite development have focused on its role in specifying the dorsoventral polarity of these structures, but a ...
J M, Britto, D, Tannahill, R J, Keynes
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2009
The Hedgehog (Hh) Pathway, originally identified in Drosophila, [1–4] is a highly conserved signaling pathway which orchestrates multiple, disparate aspects of embryogenesis, development and tissue remodeling in a wide spectrum of systems [5–8]. This is usually accomplished by autocrine/paracrine signaling and aims to control the size and localization ...
Alessia Omenetti, Anna Mae Diehl
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The Hedgehog (Hh) Pathway, originally identified in Drosophila, [1–4] is a highly conserved signaling pathway which orchestrates multiple, disparate aspects of embryogenesis, development and tissue remodeling in a wide spectrum of systems [5–8]. This is usually accomplished by autocrine/paracrine signaling and aims to control the size and localization ...
Alessia Omenetti, Anna Mae Diehl
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Science Signaling, 2011
N-terminal palmitoylation appears to position multimeric complexes of Sonic hedgehog such that protease cleavage alleviates an autoinhibitory interaction.
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N-terminal palmitoylation appears to position multimeric complexes of Sonic hedgehog such that protease cleavage alleviates an autoinhibitory interaction.
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Sonic Hedgehog on Microparticles and Neovascularization
2012Neovascularization represents a pivotal process consisting in the development of vascular network during embryogenesis and adult life. Postnatally, it arises mainly through angiogenesis, which has physiological and pathological roles in health and disease.
Soleti, Raffaella +1 more
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Sonic hedgehog relates to colorectal carcinogenesis
Journal of Gastroenterology, 2009The activation of Hedgehog signaling, which is critical to normal mammalian gastrointestinal development, is implicated in the development of various tumors, including colorectal cancer. In the pancreas, a precursor lesion overexpresses the Sonic hedgehog (Shh) when compared with normal tissue and cancer.
Kozo, Yoshikawa +8 more
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Clinical calcium, 2005
We investigated ectopic cartilage and bone formation induced by transplantation of cells which were transfected with Sonic hedgehog (Shh) cDNA encoding amino-terminal peptide for gene therapy in bone regeneration. These results indicated Shh regulated early chondrogenesis and stimulation of prechondrocytes, and consequently the synergistic effects of ...
Hisashi, Hattori +2 more
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We investigated ectopic cartilage and bone formation induced by transplantation of cells which were transfected with Sonic hedgehog (Shh) cDNA encoding amino-terminal peptide for gene therapy in bone regeneration. These results indicated Shh regulated early chondrogenesis and stimulation of prechondrocytes, and consequently the synergistic effects of ...
Hisashi, Hattori +2 more
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Comparative genomics on Sonic Hedgehog orthologs
Oncology Reports, 2005Sonic hedgehog (SHH), Indian hedgehog (IHH), and Desert hedgehog (DHH) are key molecules for the integrome network in oncology and regenerative medicine. Soluble Hedgehog ligands bind to Patched receptor to activate Smoothened seven-transmembrane receptor with Frizzled domain. KIF27 and KIF7 are human homologs of Drosophila Costal-2 (Cos2), associating
Yuriko, Katoh, Masaru, Katoh
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Sox2 Requirement in Sonic Hedgehog-Associated Medulloblastoma
Cancer Research, 2013Abstract The transcription factor Sox2 has been shown to play essential roles during embryonic development as well as in cancer. To more precisely understand tumor biology and to identify potential therapeutical targets, we thoroughly investigated the expression and function of Sox2 in medulloblastoma, a malignant embryonic brain ...
Ahlfeld, J +5 more
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