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Effects of Isoxazolyl Steroids on Key Genes of Sonic Hedgehog Cascade Expression in Tumor Cells. [PDF]
Aleksandrova A +10 more
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Examination of piperonyl butoxide developmental toxicity as a Sonic hedgehog pathway inhibitor targeting limb and palate morphogenesis. [PDF]
Rivera-González KS +2 more
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Life, death and Sonic hedgehog
BioEssays, 2000The secreted glycoprotein Sonic hedgehog (SHH), a vertebrate homologue of the Drosophila segment polarity gene Hedgehog, is essential for the development of diverse tissues during embryogenesis. Studies of SHH function during neural tube and somite development have focused on its role in specifying the dorsoventral polarity of these structures, but a ...
J M, Britto, D, Tannahill, R J, Keynes
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2009
The Hedgehog (Hh) Pathway, originally identified in Drosophila, [1–4] is a highly conserved signaling pathway which orchestrates multiple, disparate aspects of embryogenesis, development and tissue remodeling in a wide spectrum of systems [5–8]. This is usually accomplished by autocrine/paracrine signaling and aims to control the size and localization ...
Alessia Omenetti, Anna Mae Diehl
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The Hedgehog (Hh) Pathway, originally identified in Drosophila, [1–4] is a highly conserved signaling pathway which orchestrates multiple, disparate aspects of embryogenesis, development and tissue remodeling in a wide spectrum of systems [5–8]. This is usually accomplished by autocrine/paracrine signaling and aims to control the size and localization ...
Alessia Omenetti, Anna Mae Diehl
openaire +1 more source
Science Signaling, 2011
N-terminal palmitoylation appears to position multimeric complexes of Sonic hedgehog such that protease cleavage alleviates an autoinhibitory interaction.
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N-terminal palmitoylation appears to position multimeric complexes of Sonic hedgehog such that protease cleavage alleviates an autoinhibitory interaction.
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