Results 261 to 270 of about 42,109 (300)

Sonic hedgehog signaling in craniofacial development

Differentiation, 2023
Mutations in SHH and several other genes encoding components of the Hedgehog signaling pathway have been associated with holoprosencephaly syndromes, with craniofacial anomalies ranging in severity from cyclopia to facial cleft to midfacial and mandibular hypoplasia.
Jingyue Xu, Paul P.R. Iyyanar, Yu Lan, Rulang Jiang   +3 more
openaire   +2 more sources

Sonic Hedgehog on Microparticles and Neovascularization

2012
Neovascularization represents a pivotal process consisting in the development of vascular network during embryogenesis and adult life. Postnatally, it arises mainly through angiogenesis, which has physiological and pathological roles in health and disease.
Soleti, Raffaella, Martinez, Maria Carmen   +1 more
openaire   +2 more sources

Life, death and Sonic hedgehog

BioEssays, 2000
The secreted glycoprotein Sonic hedgehog (SHH), a vertebrate homologue of the Drosophila segment polarity gene Hedgehog, is essential for the development of diverse tissues during embryogenesis. Studies of SHH function during neural tube and somite development have focused on its role in specifying the dorsoventral polarity of these structures, but a ...
J M, Britto, D, Tannahill, R J, Keynes
openaire   +2 more sources

Sonic Hedgehog, the Penis and Erectile Dysfunction: A Review of Sonic Hedgehog Signaling in the Penis

Current Pharmaceutical Design, 2005
The sinusoid anatomy of the penis is complex and requires complicated interaction between smooth muscle and endothelium in order to maintain homeostasis in the adult. The morphogen, Sonic hedgehog (Shh), is a crucial regulator of these processes, along with its down stream targets patched (Ptc), Hox, bone morphogenetic proteins (BMP's), vascular ...
C A, Podlasek, C L, Meroz, H, Korolis, Y, Tang, K E, McKenna, K T, McVary   +5 more
openaire   +2 more sources

Sonic hedgehog relates to colorectal carcinogenesis

Journal of Gastroenterology, 2009
The activation of Hedgehog signaling, which is critical to normal mammalian gastrointestinal development, is implicated in the development of various tumors, including colorectal cancer. In the pancreas, a precursor lesion overexpresses the Sonic hedgehog (Shh) when compared with normal tissue and cancer.
Kozo, Yoshikawa, Mitsuo, Shimada, Hidenori, Miyamoto, Jun, Higashijima, Tomohiko, Miyatani, Masanori, Nishioka, Nobuhiro, Kurita, Takashi, Iwata, Hisanori, Uehara   +8 more
openaire   +2 more sources

Comparative genomics on Sonic Hedgehog orthologs

Oncology Reports, 2005
Sonic hedgehog (SHH), Indian hedgehog (IHH), and Desert hedgehog (DHH) are key molecules for the integrome network in oncology and regenerative medicine. Soluble Hedgehog ligands bind to Patched receptor to activate Smoothened seven-transmembrane receptor with Frizzled domain. KIF27 and KIF7 are human homologs of Drosophila Costal-2 (Cos2), associating
Yuriko, Katoh, Masaru, Katoh
openaire   +2 more sources

[Sonic hedgehog].

Clinical calcium, 2005
We investigated ectopic cartilage and bone formation induced by transplantation of cells which were transfected with Sonic hedgehog (Shh) cDNA encoding amino-terminal peptide for gene therapy in bone regeneration. These results indicated Shh regulated early chondrogenesis and stimulation of prechondrocytes, and consequently the synergistic effects of ...
Hisashi, Hattori, Hideki, Mizutani, Minoru, Ueda   +2 more
openaire   +1 more source

Sonic hedgehog is essential to foregut development

Nature Genetics, 1998
Congenital malformation of the foregut is common in humans, with an estimated incidence of 1 in 3000 live births, although its aetiology remains largely unknown. Mice with a targeted deletion of Sonic hedgehog (Shh) have foregut defects that are apparent as early as embryonic day 9.5, when the tracheal diverticulum begins to outgrow.
Y, Litingtung, L, Lei, H, Westphal, C, Chiang   +3 more
openaire   +2 more sources