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SONODYNAMIC THERAPY (SDT) AND GENE THERAPY
CARDIOMETRY, 2023One in Four Deaths in Japan Caused by Cancer. Cancer is the most common cause of death for Japanese people who are 40 and over, while suicide is the leading cause among young people.
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Sonodynamic therapy-derived multimodal synergistic cancer therapy
Cancer Letters, 2021Sonodynamic therapy (SDT) represents a promising modality that provides the possibility of non-invasively eliminating solid tumors in a site-directed manner. In light of the complexity and heterogeneity of tumors, more and more studies are attempting to combine SDT with other therapeutic methods so as to achieve better tumor treatment effect, which ...
Mimi, Xu +6 more
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The promise of sonodynamic therapy
Cancer and Metastasis Reviews, 2013Sonodynamic therapy is a potential cancer treatment modality that has been gaining support due to its effectiveness in both in vitro and in vivo studies. The therapeutic method combines ultrasonic irradiation with drugs known as sonosensitizers that amplify its ability to inflict preferential damage on malignant cells.
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Multifunctional sonosensitizers in sonodynamic cancer therapy
Chemical Society Reviews, 2020Phototherapy, including photodynamic therapy and photothermal therapy, has the potential to treat several types of cancer.
Subin Son +10 more
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Sonochemistry of sonodynamic therapy
The Journal of the Acoustical Society of America, 1998Sonodynamic therapy is a promising modality for cancer treatment based on the synergistic effect of cell killing by a combination of drugs (sonosensitizers) and ultrasound. The effectiveness of sonodynamic therapy was demonstrated in cell studies and in tumor-bearing animals.
Peter Riesz, Vladimir Misik
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Ultrasound Dose Fractionation in Sonodynamic Therapy
Ultrasound in Medicine & Biology, 2010Sonodynamic therapy (SDT) is a new modality in cancer therapy and it is based on preferential uptake and/or retention of a sonosensitizing drug in tumor tissues and subsequent activation of the drug by ultrasound. The dose fractionation effect in radiation therapy has been known for more than a century, but it is not reported in SDT so far.
Amir H, Barati, Manijeh, Mokhtari-Dizaji
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Sonodynamic therapy: A potential treatment for atherosclerosis
Life Sciences, 2018Atherosclerosis (AS), a chronic arterial disease, is one of the major causes of morbidity and mortality worldwide. Several treatment modalities have been demonstrated to be effective in treating AS; however, the mortality rate due to AS remains high. Sonodynamic therapy (SDT) is a promising new treatment using low-intensity ultrasound in combination ...
Chi, Geng +8 more
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Free Radical Intermediates in Sonodynamic Therapy
Annals of the New York Academy of Sciences, 2000Abstract: Current understanding of the mechanism of sonodynamic action (i.e. the ultrasound‐dependent enhancement of the cytotoxic action of certain drugs ‐ sonosensitizers) with potential applications for cancer therapy is presented. The experimental evidence suggests that sonosensitization is due to the chemical activation of sonosensitizers inside ...
V, Misík, P, Riesz
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Studies On Sonodynamic Cancer Therapy
Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 1992Chemical agents such as hematoporphyrin have been found to have a sonochemical activity to induce anti-tumor effects. The same kind of sonochemical reactions producing active oxygen species has been demonstrated to be localized with a highly focused ultrasound in a specially developed tissue-mimicking phantom.
null Umemura +4 more
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Combinations with Sonodynamic Therapy
2023Like photodynamic therapy, sonodynamic therapy is based on ultrasonic activation of a sonodynamic therapy sensitizer to kill disease cells by production of reactive oxygen species in excess of what can be handled by cellular redox homeostasis biochemical pathways.
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