Results 91 to 100 of about 3,188 (200)

P12.28.A A CLINICAL UPDATE OF A FIRST-IN-HUMAN PHASE 0/1 TRIAL OF 5-AMINOLEVULINIC ACID SONODYNAMIC THERAPY (5-ALA SDT) IN RECURRENT GLIOBLASTOMA.

Neuro-Oncology
Abstract BACKGROUND 5-ALA sonodynamic therapy is a first-in-class drug-device therapy exploiting the heme synthesis pathway in glioblastoma (GBM). Following IV 5-ALA administration, aberrant tumor metabolism results in protoporphyrin-IX (PpIX) accumulation.
Sanai, N, Tien, A, Tovmasyan, A, Chang, Y, Margaryan, T, Hendrickson, K, Eschbacher, J, Yoo, W, Harmon, J, Hong, A, Quarles, C, Alhilali, L, Barani, I, Mirzadeh, Z, Mehta, S   +14 more
openaire   +1 more source

Metabolism‐Regulating Nanomedicines for Cancer Therapy

Advanced NanoBiomed Research, Volume 6, Issue 1, January 2026.
This review highlights metabolism‐regulating nanomedicines designed to target glycolytic, lipid, amino acid, and nucleotide pathways in tumors. By incorporating metabolism‐regulating agents into versatile nanocarriers such as liposomes, micelles, dendrimers, and engineered bacteria, these platforms achieve targeted delivery, controlled release ...
Xiao Wu, Shiyi Geng, Jian Yang
wiley   +1 more source

Oxygen‐carrying semiconducting polymer nanoprodrugs induce sono‐pyroptosis for deep‐tissue tumor treatment

Exploration
Sonodynamic therapy (SDT) has been explored for cancer therapy, especially for deep tumors due to its low tissue penetration restriction. The therapeutic efficacy of SDT is limited due to the complicated tumor microenvironment.
Fengshuo Wang, Yongliang Fan, Yue Liu, Xiangxin Lou, Linawati Sutrisno, Shaojun Peng, Jingchao Li   +6 more
doaj   +1 more source

Nanofabricated Bacterial Cell Walls with Intrinsic Peroxidase‐Mimicking and Sonodynamic Activities for Cancer Combination Treatment

Advanced Science
Bacterial cancer therapy recently has been attracting more and more attention because of its multiple functions to fight cancer. Porphyromonas gingivalis (Pg), a Gram‐negative pathogenic bacterium, acquires protoporphyrin IX (PpIX) and iron from heme and
Meng Yang, Yang Meng, Junling Li, Liya Bai, Yuanyuan Cheng, Yuanyuan Liu, Mingxin Cao, Xiaoying Yang, Yinsong Wang, Yang Liu   +9 more
doaj   +1 more source

Preparation of La2(WO4)3/CuWO4 composite nanomaterials with enhanced sonodynamic anti-glioma activity

Frontiers in Bioengineering and Biotechnology
IntroductionSonodynamic therapy (SDT) is an innovative way to treat tumors by activating sonosensitizers via ultrasound (US). The development of sonosensitizers with high sonodynamic activity is the key to promote the clinical application of SDT ...
Fang-Yu Liu, Xin Wang, Ye-Fu Liu
doaj   +1 more source

Apoptosis of THP-1 derived macrophages induced by sonodynamic therapy using a new sonosensitizer hydroxyl acetylated curcumin.

PLoS ONE, 2014
Curcumin is extracted from the rhizomes of the traditional Chinese herb Curcuma longa. Our previous study indicated curcumin was able to function as a sonosensitizer.
Longbin Zheng, Xinyong Sun, Xing Zhu, Fengxiang Lv, Zhaoyu Zhong, Feng Zhang, Wenhui Guo, Wenwu Cao, Liming Yang, Ye Tian   +9 more
doaj   +1 more source

ROS-Dependent Activation of Autophagy through the PI3K/Akt/mTOR Pathway Is Induced by Hydroxysafflor Yellow A-Sonodynamic Therapy in THP-1 Macrophages [PDF]

, 2017
Monocyte-derived macrophages participate in infaust inflammatory responses by secreting various types of proinflammatory factors, resulting in further inflammatory reactions in atherosclerotic plaques.
Jiayuan Kou, Liming Yang, Xiaobo Han, Xuesong Li, Ye Tian, Yinghong Zheng, Yueqing Jiang, Zhaoyu Zhong, Zhongni Liu   +8 more
core   +2 more sources

Synergistic SDT/cuproptosis therapy for liver hepatocellular carcinoma: enhanced antitumor efficacy and specific mechanisms

Journal of Nanobiotechnology
The efficacy of sonodynamic therapy (SDT), an emerging approach for tumor treatment, is hindered by the high levels of the antioxidant glutathione (GSH) in the tumor microenvironment (TME).
Yucao Sun, Yichi Chen, Bolin Wu, Helin Li, Yijun Wang, Xiaodong Wang, Liwen Deng, Kuikun Yang, Xiuhong Wang, Wen Cheng   +9 more
doaj   +1 more source

Artesunate Enhances the Cytotoxicity of 5-Aminolevulinic Acid-Based Sonodynamic Therapy against Mouse Mammary Tumor Cells In Vitro [PDF]

, 2017
Sonodynamic therapy (SDT) kills tumor cells through the synergistic effects of ultrasound (US) and a sonosensitizer agent. 5-Aminolevulinic acid (5-ALA) has been used as a sonodynamic sensitizer for cancer treatment.
10780/profile-ja.html, 116, 20304553, Azuma, Kazuo, Imagawa, Tomohiro, Ishizuka, Masahiro, Itoh, Norihiko, Kurahashi, Tsukasa, Murahata, Yusuke, Okamoto, Yoshiharu, Osaki, Tomohiro, Tanaka, Tohru, Tsuka, Takeshi, Uto, Yoshihiro, Yamanaka, Nobuyasu, アズマ, カズオ, アズマ, カズオ, イシヅカ, マサヒロ, イシヅカ, マサヒロ, イトウ, ノリヒコ, イトウ, ノリヒコ, イマガワ, トモヒロ, イマガワ, トモヒロ, ウト, ヨシヒロ, オオサキ, トモヒロ, オオサキ, トモヒロ, オカモト, ヨシハル, オカモト, ヨシハル, クラハシ, ツカサ, クラハシ, ツカサ, タナカ, トオル, タナカ, トオル, ツカ, タケシ, ツカ, タケシ, ムラハタ, ユウスケ, ムラハタ, ユウスケ, ヤマナカ, ノブヤス, ヤマナカ, ノブヤス, 宇都, 義浩   +38 more
core  

Enhanced selective sonosensitizing efficacy of ultrasound-based anticancer treatment by targeted gold nanoparticles [PDF]

, 2016
partially_open9noThis study investigates cancer targeted gold nanoparticles as ultrasound sensitizers for the treatment of cancer.his study investigates cancer targeted gold nanoparticles as ultrasound sensitizers for the treatment of cancer.
Brazzale, Chiara, Caliceti, Paolo, Canaparo, Roberto, Durando, Gianni, Fantozzi, Roberto, Foglietta, Federica, Racca, Luisa, Salmaso, Stefano, Serpe, Loredana   +8 more
core   +1 more source