Results 81 to 90 of about 3,319 (195)

Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang, Bowen Li, Pan Tang, Fanchen Yan, Shuxin Wang, Guiying Leng, Panduo Dawa, Yuansi Chen, Yihan Guo, Pan Yang, Yi Li, Siyu Liu, Erdan Dong, Siyuan Qin, Zhoufeng Wang   +14 more
wiley   +1 more source

Cell-membrane targeting sonodynamic therapy combination with FSP1 inhibition for ferroptosis-boosted immunotherapy

Materials Today Bio
Cell membrane targeting sonodynamic therapy could induce the accumulation of lipid peroxidation (LPO), drive ferroptosis, and further enhances immunogenic cell death (ICD) effects.
Jian Chen, Qiyu Zhan, Lie Li, Simin Xi, Longmei Cai, Ruiyuan Liu, Lujia Chen   +6 more
doaj   +1 more source

Biomimetic Cell Membrane‐Coated MOFs System for Targeted Cancer Therapy

Advanced Science, Volume 13, Issue 21, 13 April 2026.
Biomimetic MOF‐based drug delivery nanoplatforms synthesized using liposomes or cell membranes as camouflage for multiple cancer therapeutics. ABSTRACT The integration of metal‐organic frameworks (MOFs) with cell membrane coatings has emerged as a revolutionary strategy to enhance the therapeutic efficacy of cancer nanomedicine.
Qilu Wu, Jia Song Deon Chon, Yuxiao Feng, Kang Liang, Shiming Li, Can Yang Zhang, Jun Ge   +6 more
wiley   +1 more source

Tumor Microenvironment Activated Cu Crosslinked Near‐Infrared Sonosensitizers for Visualized Cuproptosis‐Enhanced Sonodynamic Cancer Immunotherapy

Advanced Science
Reactive oxygen species (ROS)‐mediated sonodynamic therapy (SDT) holds increasing potential in treating deep‐seated tumor owing to the high tissue‐penetration depth.
Jinyan Hu, Lang Yan, Zhi Cao, Bijiang Geng, Xiqian Cao, Bing Liu, Jiaming Guo, Jiangbo Zhu   +7 more
doaj   +1 more source

Ultrasound‐Responsive Engineered Bacteria for Targeted Cancer Therapy: Strategies, Mechanisms, and Applications

Advanced Science, Volume 13, Issue 20, 9 April 2026.
This review elucidates URB design strategies, including genetic and physicochemical modifications, while dissecting the synergistic mechanisms governing spatiotemporal control. It further evaluates applications in targeted drug delivery, gene modulation, and immunotherapy, finally offering perspectives on overcoming translational barriers for clinical ...
Xueyao Wang, Wenjing Xu, Yafang Lu, Huaibin Yu, Zhengbao Zha, Xijun Zhang   +5 more
wiley   +1 more source

Nanozymes for Liver Disease Therapy: Advances in Catalytic Activity, Targeting Strategies, and Clinical Translation

Advanced Science, Volume 13, Issue 20, 9 April 2026.
Nanozymes, as enzyme‐mimicking nanomaterials, exhibit unique catalytic properties for the treatment of liver diseases. By regulating redox homeostasis, modulating immune responses, and enabling targeted delivery, nanozymes overcome the limitations of natural enzymes.
Xiandi Meng, Ge Zhu, Siyu Sun, Wenbo Yao, Yuning Zhang, Yong‐Guang Yang, Tianmeng Sun   +6 more
wiley   +1 more source

Cisplatin‐coordinated copolythiophene for synergistic chemotherapy and sonodynamic therapy of tumor

Smart Molecules
Sonodynamic therapy (SDT) is a novel cancer treatment type showing the advantages of high tissue penetration ability, non‐invasion, low systemic toxicity, and high selectivity.
Yuanyu Tang, E. Pang, Pan Zhu, Qiuxia Tan, Shaojing Zhao, Benhua Wang, Chaoyi Yao, Xiangzhi Song, Minhuan Lan   +8 more
doaj   +1 more source

Recent Advances in Tetrahedral Framework Nucleic Acids for Multimodal Synergistic Cancer Therapy

Aggregate, Volume 7, Issue 4, April 2026.
This review summarizes recent advances in tFNA‐based multimodal cancer therapy, including structural features, delivery strategies, and therapeutic regimens addressing key challenges in cancer treatment. We outline design principles, address translational hurdles, and highlight intelligent response and immune regulation as promising directions to ...
Zishan Huang, Zhitong Chen, Zhiyu Zhang, Hong Sun, Xujuan Li, Zhaogang Sun, Hongqian Chu, Wenjing Liu   +7 more
wiley   +1 more source

New Approaches to Photodynamic Therapy from Type I, II and III to Type IV Using One or More Photons [PDF]

, 2017
Photodynamic therapy (PDT) is an alternative cancer treatment to conventional surgery, radiotherapy and chemotherapy. It is based on activating a drug with light that triggers the generation of cytotoxic species that promote tumour cell killing.
Bisby, RH, Botchway, SW, Parker, AW, Scherer, KM   +3 more
core   +2 more sources

P12.28.A A CLINICAL UPDATE OF A FIRST-IN-HUMAN PHASE 0/1 TRIAL OF 5-AMINOLEVULINIC ACID SONODYNAMIC THERAPY (5-ALA SDT) IN RECURRENT GLIOBLASTOMA.

Neuro-Oncology
Abstract BACKGROUND 5-ALA sonodynamic therapy is a first-in-class drug-device therapy exploiting the heme synthesis pathway in glioblastoma (GBM). Following IV 5-ALA administration, aberrant tumor metabolism results in protoporphyrin-IX (PpIX) accumulation.
Sanai, N, Tien, A, Tovmasyan, A, Chang, Y, Margaryan, T, Hendrickson, K, Eschbacher, J, Yoo, W, Harmon, J, Hong, A, Quarles, C, Alhilali, L, Barani, I, Mirzadeh, Z, Mehta, S   +14 more
openaire   +1 more source