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Ultrasound in Medicine & Biology, 2011
Purpose: The purpose of this study was to investigate the physical mechanisms of sonoporation, to understand and ameliorate ultra- sound-assisted drug and gene delivery. Sonoporation is the transient per- meabilisation of a cell membrane with help of ultrasound and/or an ultrasound contrast agent, allowing for the trans-membrane delivery and cellular ...
Delalande, Anthony +3 more
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Purpose: The purpose of this study was to investigate the physical mechanisms of sonoporation, to understand and ameliorate ultra- sound-assisted drug and gene delivery. Sonoporation is the transient per- meabilisation of a cell membrane with help of ultrasound and/or an ultrasound contrast agent, allowing for the trans-membrane delivery and cellular ...
Delalande, Anthony +3 more
openaire +2 more sources
Application of liposomes to sonoporation
Ultrasound in Medicine & Biology, 2006A method to prepare liposomes is presented. Liposomes made in our laboratory were characterized acoustically and optically. The phase velocity and attenuation of liposomes in suspension (concentration = 10(9)/mL) were measured, ranging from 2 to 14 MHz, using ultrasound spectroscopy.
Junru, Wu +4 more
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2011
{"references": ["Krestan C. Ultraschallkontrastmittel: Substanzklassen, Pharmakokinetik, klinische Anwendungen, Sicherheitsaspekte. Radiologe 2005 45:513\u2013519.", "Postema M, Schmitz G. Bubble dynamics involved in ultrasonic imaging. Expert Rev Mol Diagn 2006 6:493\u2013502.", "Schutt EG, Klein DH, Mattrey RM, Riess JG.
Postema, Michiel +2 more
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{"references": ["Krestan C. Ultraschallkontrastmittel: Substanzklassen, Pharmakokinetik, klinische Anwendungen, Sicherheitsaspekte. Radiologe 2005 45:513\u2013519.", "Postema M, Schmitz G. Bubble dynamics involved in ultrasonic imaging. Expert Rev Mol Diagn 2006 6:493\u2013502.", "Schutt EG, Klein DH, Mattrey RM, Riess JG.
Postema, Michiel +2 more
openaire +4 more sources
Controlled Cavitation and Sonoporation in Microfluidics
Volume 2: Biomedical and Biotechnology Engineering, 2007Cavitation – the growth and collapse of mostly empty bubbles — is commonly attributed to large scale or very rapid flows, e.g. at ship propellors or at fuel injection nozzles. Cavitation is very aggressive to materials and one reason is its ability to focus fluid flows to very small scales; the bubbles concentrate the energy from the fluid during their
Ohl, Claus Dieter +4 more
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Sonoporation: Concept and Mechanisms
2016Contrast agents for ultrasound are now routinely used for diagnosis and imaging. In recent years, new promising possibilities for targeted drug delivery have been proposed that can be realized by using the microbubble composing ultrasound contrast agents (UCAs). The microbubbles can carry drugs and selectively adhere to specific sites in the human body.
Ayache, Bouakaz +2 more
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Compact Cell Sonoporation Device for Performing Sonoporation Experiments on Adherent Cells
2021 IEEE International Ultrasonics Symposium (IUS), 2021This paper reports a compact sonoporation device for 24 and 96 well cell culture plates. The proposed device is designed to be used in in vitro studies on adherent cells. K-Wave toolbox was used to model the pressure field and determine a uniform region where cells could be then exposed to ultrasound.
Mohammad Jahromi +3 more
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Ultrasound Sonoporation in Pancreatic Adenocarcinoma
Ultrasound in Medicine & Biology, 2015ObjectivesThe objectives of this Phase I study were to investigate the safety and the ability of inducing sonoporation in a clinical setting, using commercially available technology, to increase the patients’ quality of life and to possibly increase the overall survival in patients with pancreatic adenocarcinoma.Methods10 Patients were treated using a ...
Odd Helge Gilja +5 more
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Sonoporation for Gene Transfer into Embryos
Cold Spring Harbor Protocols, 2011INTRODUCTIONSonoporation is a method for the introduction of genes into tissues such as those of chick embryos. It enables gene incorporation into target tissue by the combination of ultrasound exposure and subsequent rupture of microbubbles. Sonoporation has several advantages: (1) It is simple, involving two main steps—preparation of a microbubble ...
Sho, Ohta +5 more
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Reparable sonoporation generated by microstreaming
The Journal of the Acoustical Society of America, 2002Reparable sonoporation was observed in Jurkat lymphocytes in suspension exposed to a vibrating Mason horn tuned to 21.4 KHz. The diameter of the horn tip was 400 μm and its transverse displacement amplitude was 7.8 μm. It was found that the shear stress associated with microstreaming surrounding the Mason-horn tip was the primary reason for the cell ...
Junru, Wu, Joel P, Ross, Jen-Fu, Chiu
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Sonoporation: Applications for Cancer Therapy
2016Therapeutic efficacy of both traditional chemotherapy and gene therapy in cancer is highly dependent on the ability to deliver drugs across natural barriers, such as the vessel wall or tumor cell membranes. In this regard, sonoporation induced by ultrasound-guided microbubble (USMB) destruction has been widely investigated in the enhancement of ...
Jiale, Qin +2 more
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