Results 71 to 80 of about 57,950 (240)

Architecture and Liturgical Functions of Skevophylakion at the Great Church St Sophia in Constantinople

Forum Theologicum Sardicense
Alexander Filov, Architecture and Liturgical Functions of Skevophylakion at the Great Church St Sophia in Constantinople This research offers a new perspective on the liturgical function of the skeuophylakion at St. Sophia Church in Constantinople.
Alexander Filov
doaj   +1 more source

Covalently Linked Peptides and Membrane Potential Enable CyaA Segment Translocation

Advanced Science, EarlyView.
Using a newly developed Droplet Interface Bilayer‐Pipette assay, the authors show that two segments of the CyaA toxin cross membranes by distinct mechanisms. One segment translocates spontaneously, whereas the translocation of the other depends on membrane potential.
Gaia Scilironi, Nicolas Carvalho, Jacinthe Frangieh, Corentin Léger, Dorothée Raoux‐Barbot, J. Iñaki Guijarro, Daniel Ladant, Sophie Cribier, Nicolas Rodriguez, Alexandre Chenal   +9 more
wiley   +1 more source

α‐Synuclein Forms Distinct Micelle‐Like Assemblies at Low Ionic Strengths

Advanced Science, EarlyView.
At high ionic strength, α‐synuclein forms diverse assemblies, including oligomers, fibrils, and condensates. Here, we show that at low ionic strength, α‐synuclein adopts a distinct, low‐abundance assembly state. These assemblies maintain a constant size above a critical concentration and do not coalesce, suggesting a micelle‐like organization ...
Sophie Hertel, Soumik Ray, Federica Saraceno, Giacomo Nisini, Georgia Nasi, Thomas Oliver Mason, Antonin Kunka, Effrosyni Agrimaki, Dannie Juul Olesen, Francesco Simone Ruggeri, Alexander K. Buell   +10 more
wiley   +1 more source

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source

Real‐Time Monitoring of Mass and Mechanical Properties in Single Cells and Multicellular Spheroids

Advanced Science, EarlyView.
This study introduces photothermally actuated microcantilevers combined with optical microscopy to simultaneously measure morphology, mass, and mechanical properties of cellular systems in real‐time. The findings link cytoplasm‐dominated mechanical energy dissipation to the Q‐factor as a novel biophysical parameter.
Ilaria Incaviglia, Giulia E. M. Ammirati, Sophie Herzog, Tommy Krug, Nico Strohmeyer, Miguel Camacho Rufino, Matthias P. Lutolf, David A. Weitz, Daniel J. Müller   +8 more
wiley   +1 more source

Accelerating Biosensor Discovery: A Computationally‐Driven Pipeline for Microplastics Monitoring

Advanced Intelligent Discovery, EarlyView.
A computationally guided pipeline unites molecular simulation, synthetic biology, electrochemical engineering, and machine learning to accelerate biosensor discovery. A Bacillus anthracis carbohydrate‐binding module is used to develop a high‐performance micro‐ and nanoplastics sensor with greatly reduced error and variability.
Gabriel X. Pereira, Marcos de C. Leite, Pedro H. M. Zanineli, Juliana N. Y. Costa, Débora M. Cunha, Sophia P. Serra, Pedro H. Sophia, Flávio M. Shimizu, Yasmin W. Moura, Célio C. Oliveira, Gabriel R. Schleder, Gabriela F. Persinoti, Leandro Merces, Renato S. Lima   +13 more
wiley   +1 more source

AI‐Based Immortality: The Ethical Advantage of the Aretai Approach

AI &Innovation, EarlyView.
ABSTRACT The convergence of artificial intelligence, digital identity technologies, and biogerontological ambitions has produced a novel set of philosophical problems that have not yet been adequately addressed within mainstream bioethical discourse. Digital life extension—encompassing AI‐generated avatars, neural data preservation, mind uploading, and
Mirko Daniel Garasic
wiley   +1 more source

NHC‐Copper(I)‐Mediated Functionalization of White Phosphorus

Angewandte Chemie, EarlyView.
White phosphorus is functionalized by N‐heterocyclic carbene supported copper(I) complexes through redox‐neutral steps. Treatment of the resulting complexes with electrophiles releases the ligands from the metal center as asymmetrically substituted organophosphorus butterfly compounds.
Thomas M. Horsley Downie, Sophia A. Vogler, Gábor Balázs, Francesco Cirigliano, Robert Wolf   +4 more
wiley   +2 more sources

Diagnosing the system: Mental health, necropolitical uncare, and the abolition of migration detention

American Journal of Community Psychology, EarlyView.
Abstract This article examines the psychological effects of migration detention in the European Union's Closed Controlled Access Center (CCAC) on Samos through an ecological lens. It explores a double normalization of suffering: the brutalization of necropolitical migration governance and the simultaneous understanding of resulting distress as an ...
Julia Manek
wiley   +1 more source

Conformation‐Selective Binding Domains of Intramolecular Chemically Induced Protein Dimerisation Systems

Angewandte Chemie, EarlyView.
Intramolecular chemically induced dimerisation transforms FK506‐ and cyclosporine A‐responsive protein pairs into high‐affinity pseudo‐allosteric switches. Holo‐selective binders isolated by mRNA display convert these switches into gain‐of‐signal biosensors and ultrasensitive ELISAs, enabling direct quantification of both immunosuppressants in ...
Zhenling Cui, Zhong Guo, Yi Jin Liew, Alessandro T. Caputo, Maria M. Fiorito, Cagla Ergun Ayva, Roxane Mutschler, Mayra Barrios Leguarca, Sophia Newton, Gia Nghi Lam, Robert Speight, Brett McWhinney, Yanulla Essie Georges, Carel Pretorius, Jacobus P.J. Ungerer, Kirill Alexandrov   +15 more
wiley   +2 more sources