Results 121 to 130 of about 55,815 (216)

AFP Stimulates Glucose Metabolic Reprogramming Contributing to Hepatocellular Carcinoma Resist Sorafenib Through Activating PI3K/AKT Signalling Pathway. [PDF]

J Cell Mol Med
Zhou Y, Feng S, Chen Y, Lin B, Li W, Dong X, Liu K, Yin Q, Li M, Zhu M.   +9 more
europepmc   +1 more source

DNMT3A Co‐Mutation and Real‐World Clinical Outcomes With Gilteritinib in FLT3‐Mutated Acute Myeloid Leukaemia Across Molecular Subgroups

eJHaem, Volume 7, Issue 4, August 2026.
ABSTRACT Introduction: Molecular co‐mutations modulate outcomes in FLT3‐mutated AML treated with gilteritinib; real‐world data stratified by DNMT3A co‐mutation status are lacking. Methods We retrospectively analysed 29 adults with R/R FLT3‐mutated AML treated at two Italian centres.
Francesca Duca, Beatrice Manghisi, Andrea Palasciano, Anna Mochi, Matteo Parma, Rosa Greco, Roberto Cairoli, Carlo Gambacorti‐Passerini, Monica Fumagalli   +8 more
wiley   +1 more source

Comparative efficacy and safety of first-line treatments for advanced hepatocellular carcinoma: a Bayesian network meta-analysis. [PDF]

Front Immunol
Su Y, Cai T, Wei J, Huang Q, Yao C, Fu L, Zheng J, Guo H, Gui X.   +8 more
europepmc   +1 more source

Management of Satellite Lesions in Hepatocellular Carcinoma: An Updated Review

Journal of Surgical Oncology, Volume 134, Issue 2, Page 157-165, August 2026.
ABSTRACT Satellite lesions, defined as microscopic or small macroscopic tumor nodules within 2 cm of a primary hepatocellular carcinoma (HCC), represent early intrahepatic dissemination and are strongly associated with aggressive tumor biology.
Andy Tran, Mohammed O. Suraju, Ihuoma Tasie, Abdelrahman K. Abdalla, Hassan Aziz   +4 more
wiley   +1 more source

GRB2 Promotes Sorafenib Resistance in Hepatocellular Carcinoma Cells Under Hypoxia by Activating the PI3K/AKT Signaling Pathway. [PDF]

J Hepatocell Carcinoma
He J, Kong Y, Wang Y, Fang Q, Wu H, Du K, Luo Y, Tan J, Yin H, Lin H, Li M.   +10 more
europepmc   +1 more source

The Role of Inflammation and Immunity in Cardiovascular Disease: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
Inflammation in cardiovascular disease is a dynamic and context‐dependent network rather than a secondary response to injury. Mitochondrial danger signaling links metabolic stress to immune activation through TLR priming, NLRP3 inflammasome amplification, cGAS–STING signaling, and immunometabolic gating, providing a basis for more precise therapeutic ...
Jiaxiang Rong, Zhen Wang, Xiaoxiao Lin, Ziwen Lei, Qianqian Huang, Hang Liu, Fei Luan, Junbo Zou, Yajun Shi   +8 more
wiley   +1 more source

Identification of Changes in the Transcriptome Profile of Human Hepatoma HepG2 Cells Exposed to Combined Sorafenib and Cannabis Treatment. [PDF]

Int J Mol Sci
Udomkritayachai K, Thiamsuk T, Jarujamrat T, Kudikhong P, Raksakhom S, Suphattana P, Khankham N, Thanawong P, Khacha-Ananda S.   +8 more
europepmc   +1 more source

Turning Cold Tumors Into Hot Tumors: Implications for Cancer Therapy

MedComm, Volume 7, Issue 8, August 2026.
Barrier‐defined strategies for cold‐to‐hot tumor conversion. Cold tumors include immune‐desert and immune‐excluded states marked by poor antigen visibility, limited T‐cell priming, stromal or vascular exclusion, metabolic stress and suppressive immune programs.
Xiao Ge, Dong Han, Jing Wang, Xinyu Dai, Chen Ma, Feihong Chen   +5 more
wiley   +1 more source

Hederagenin Promotes Sorafenib Sensitivity in Hepatocellular Carcinoma Through Suppressing SLC7A11 Expression and Inducing Ferroptosis. [PDF]

Food Sci Nutr
Jiang HM, Zhou YW, Zhang JY, Pan FZ, Zhang JF, Zhang YG.   +5 more
europepmc   +1 more source

Isothiocyanates as Ferroptosis Inducers to Promote Cancer Cell Death

Phytotherapy Research, Volume 40, Issue 8, Page 5119-5131, August 2026.
ABSTRACT Cancer remains a leading cause of global mortality, with the therapeutic efficacy of anticancer drugs often hampered by late diagnosis and the development of chemotherapy resistance. Ferroptosis is an iron‐dependent form of regulated non‐apoptotic cell death driven by lipid peroxidation.
Valentina Citi, Renda Chahna, Francesca Maffei, Alma Martelli, Vincenzo Calderone, Carmela Fimognari, Eleonora Turrini   +6 more
wiley   +1 more source