Results 111 to 120 of about 70,416 (256)

Sorafenib in advanced hepatocellular carcinoma

, 2008
Background No effective systemic therapy exists for patients with advanced hepatocellular carcinoma. A preliminary study suggested that sorafenib, an oral multikinase inhibitor of the vascular endothelial growth factor receptor, the platelet-derived ...
Forner, Alejandro, Galle, Peter R, M. Shan, M. Moscovici, J. F. Blanc, Gane, Edward, J. Bruix, Greten, Tim F, Blanc, Jean‐Frederic, E. Gane, S. Zeuzem, S. Ricci, de Oliveira, Andre Cosme, A. Santoro, Moscovici, Marius, A. Forner, Greten, Tim F., J. F. Seitz, V. Mazzaferro, Haussinger, Dieter, L. Bolondi, Llovet, Josep M., Raoul, Jean-Luc, J. M. Llovet, J. L. Raoul, Van Vlierberghe, Hans, Shan, Minghua, SHARP Investigators Study Group, the, Cosme de Oliveira, Andre, D. Häussinger, Galle, Peter R., Seitz, Jean-François, P. Hilgard, P. R. Galle, Mazzaferro, Vincenzo, C. Porta, Bruix, Jordi, Llovet, Josep M, Porta, Camillo, Blanc, Jean-Frederic, Schwartz, Myron, T. Giannaris, I. Borbath, Hilgard, Philip, D. Voliotis, SHARP Investigators Study Group, Santoro, Armando, M. Schwartz, Ricci, Sergio, T. F. Greten, Bolondi, Luigi, Borbath, Ivan, Giannaris, Tom, A. C. de Oliveira, Zeuzem, Stefan, Voliotis, Dimitris   +55 more
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Mechanisms of Sorafenib Resistance in HCC Culture Relate to the Impaired Membrane Expression of Organic Cation Transporter 1 (OCT1) [PDF]

Srinivas Chava,1 Nergiz Ekmen,2 Pauline Ferraris,1 Yucel Aydin,2 Krzysztof Moroz,1 Tong Wu,1 Swan N Thung,3 Srikanta Dash1,2,4 1Department of Pathology and Laboratory Medicine, Tulane University Health Sciences Center, New Orleans, LA, USA; 2Department ...
Moroz K, Dash S, Ferraris P, Ekmen N, Aydin Y, Wu T, Chava S, Thung SN   +7 more
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Cyclodextrin polymers as nanocarriers for sorafenib

, 2017
Polymeric nanoparticles based on cyclodextrins are currently undergoing clinical trials as new promising nanotherapeutics. In light of this interest, we investigated cyclodextrin cross-linked polymers with different lengths as carriers for the poorly ...
Viale, Maurizio, Vittorio Bertone, Bertone, Vittorio, Vecchio, Graziella, Valentina Giglio, Graziella Vecchio, Giglio, Valentina, Vaccarone, Rita, Maurizio Viale, Irena Maric, Maric, Irena, Rita Vaccarone   +11 more
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Chaetocin Induces Ferroptosis in Cisplatin‐Resistant Ovarian Cancer Cells Through Neddylation‐Mediated TFRC Upregulation

Phytotherapy Research, EarlyView.
Chaetocin induces ferroptosis in cisplatin‐resistant ovarian cancer cells through neddylation‐mediated TFRC upregulation. ABSTRACT Ovarian cancer (OV) is a highly lethal gynecological tumor, often developing platinum chemotherapy resistance and treatment failure.
Hanfei Xie, Wumin Dai, Lu Sun, Wangang Gong, Tao Zhu, Yingli Zhang   +5 more
wiley   +1 more source

Matrix stiffness regulates glucose-6-phosphate dehydrogenase expression to mediate sorafenib resistance in hepatocellular carcinoma through the ITGB1-PI3K/AKT pathway

Cell Death and Disease
Sorafenib is an antiangiogenic and antiproliferative chemotherapeutic drug that plays a crucial role in the treatment of patients with advanced hepatocellular carcinoma (HCC). However, resistance to sorafenib greatly limits its therapeutic efficacy. This
Ruimei Ren, Shan Zhang, Zhan Peng, Xiaomeng Ji, Hao Song, Qiuxiao Wang, Xiangyin Sun, Huiyu Wang, Yinying Dong   +8 more
doaj   +1 more source

Roles and Mechanisms of Ferroptosis in Sorafenib Resistance for Hepatocellular Carcinoma [PDF]

Ruyuan Liu,1,* Huanyu Cui,1,* Di Li,1 Xuefeng Guo,1 Zhengbao Zhang,1 Shengkui Tan,1,2 Xiaonian Zhu1 1Guangxi Key Laboratory of Environmental Exposomics and Entire Lifecycle Health, Guilin Medical University, Guilin, 541199, People’s Republic of ...
Li D, Zhang Z, Guo X, Cui H, Tan S, Liu R, Zhu X   +6 more
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A lysosome‐targeted ultra‐sensitive viscosity probe for monitoring viscosity alterations during chemotherapy

Smart Molecules, EarlyView.
A novel chemosensing platform based on a molecular rotor architecture is established for specific, dynamic detection of lysosomal viscosity. The platform allows real‐time tracking of lysosomal viscosity fluctuations induced by various chemotherapeutic agents, highlighting its significant potential as a powerful tool for early cancer diagnostics and ...
Haoyang Song, Hui Bian, Lei Liu, Gahyeon Park, Bingqing Sun, Qiongzheng Hu, Juyoung Yoon   +6 more
wiley   +1 more source

Sorafenib-loaded hydroxyethyl starch-TG100-115 micelles for the treatment of liver cancer based on synergistic treatment

, 2019
Tumor microenvironment is closely related to the occurrence and development of liver cancer. Tumor-associated macrophages (TAMs) are an important part of tumor microenvironment promoting tumor deterioration and metastasis by inhibiting immune cells ...
Guofei Li (809620), Limei Zhao (289815)
core   +1 more source

Targeting the CD47–SIRPα phagocytic checkpoint in cancer: Biology, translational opportunities, and next‐generation therapeutic strategies

Smart Molecules, EarlyView.
The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Ruimei Zhou, Lingjie Jing, Jianping Zhang, Cheng Guo, Quanjun Yang   +4 more
wiley   +1 more source

Regorafenib indicated as monotherapy for the treatment of adult patients with hepatocellular carcinoma who have been previously treated with sorafenib

, 2018
En este informe de la European Network for Health Technology Assessment (EUnetHTA), se evalúa la eficacia y seguridad de regorafenib en el tratamiento de pacientes adultos con carcinoma hepatocelular que han sido tratados previamente con sorafenib. AETSA

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