Results 91 to 100 of about 70,416 (256)

The analysis of the long-term outcomes of sorafenib therapy in routine practice in imatinib and sunitinib resistant gastrointestinal stromal tumors (GIST)* [PDF]

, 2017
Aim of the study was to analyze the outcome of treatment and factors predicting results of sorafenib therapy in inoperable/metastatic CD117-positive GIST patients after failure on imatinib and sunitinib.
Hanna Kosela-Paterczyk, Slawomir Falkowski, Iwona Lugowska, Beata Jagielska, Anna Klimczak, Elzbieta Bylina, Piotr Rutkowski, Tomasz Switaj, Jolanta Andrzejuk, Katarzyna Kozak   +9 more
core   +1 more source

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

Clinical factors related to long-term administration of sorafenib in patients with hepatocellular carcinoma

, 2012
Shunsuke Nojiri,1 Atsunori Kusakabe,1 Kei Fujiwara,1 Noboru Shinkai,1 Kentaro Matsuura,1 Etsuko Iio,1 Tomokatsu Miyaki,1 Tomoyuki Nomura,2 Satoshi Sobue,3 Hitoshi Sano,4 Izumi Hasegawa,5 Tomoyoshi Ohno,5 Yoshitsugu Takahashi,6 Etsuro Orito,7 Takashi ...
Iio E, Sobue S, Nojiri S, Matsuura K, Takahashi Y, Fujiwara K, Joh T, Ohno T, Orito E, Shinkai N, Nomura T, Miyaki T, Kusakabe A, Sano H, Hasegawa I   +14 more
core  

Everolimus augments the effects of sorafenib in a syngeneic orthotopic model of hepatocellular carcinoma [PDF]

, 2011
Sorafenib targets the Raf/mitogen-activated protein kinase, VEGF, and platelet-derived growth factor pathways and prolongs survival patients in advanced hepatocellular carcinoma (HCC).
McSheehy, Paul M., St-Pierre, Marie V, Ruslan Hlushchuk, Jean-François Dufour, Piguet, Anne-Christine, McSheehy, Paul M. J., Valentin Djonov, McSheehy, Paul M J, Dufour, Jean-François, Vesna Radojevic, St-Pierre, Marie V., Bettina Saar, Djonov, Valentin, Marie V. St-Pierre, Luigi Terracciano, Terracciano, Luigi, Hlushchuk, Ruslan, Maresa Afthinos, Radojevic, Vesna, Afthinos, Maresa, Paul M.J. McSheehy, Saar, Bettina, Anne-Christine Piguet   +22 more
core   +1 more source

Gut Enterococcus faecium derived leucic acid mediates the antiobesity effect of dietary fiber

iMeta, EarlyView.
This study identified Enterococcus faecium as a gut bacterium with anti‐obesity activity, which alleviated adipocyte hypertrophy, dyslipidemia, and hepatic steatosis by converting leucine into leucic acid (LEA) to regulate mitochondrial oxidative phosphorylation.
Baifei Hu, Qianru Gao, Junmin Hui, Mengqiong Wang, Haiyan Gao, Kai Li, Junping Zheng, Zhe Dai, Songlin Liu, Hongtao Liu   +9 more
wiley   +1 more source

Sorafenib for the treatment of unresectable hepatocellular carcinoma

, 2008
Junji FuruseDepartment of Internal Medicine, Medical Oncology, School of Medicine, Kyorin UniversityAbstract: Raf kinases and vascular endothelial growth factor receptor (VEGFR) and platelet-derived growth factor receptor (PDGFR) tyrosine kinases are ...
Junji Furuse
core  

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential

iNew Medicine, EarlyView.
ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang, Xinyan Li, Honglu Shi, Gaolei Song, Zhifu Xie, Jingya Li   +5 more
wiley   +1 more source

Tolerability of oral sorafenib in pet dogs with a diagnosis of cancer

, 2017
Amanda Foskett, Christina Manley, Rebecca Naramore, Ira K Gordon, Bridget M Stewart, Chand Khanna The Oncology Service, LLC, Leesburg, VA, USA Abstract: Sorafenib is a multi-target small molecule inhibitor of the RAF kinase ...
Foskett A, Manley C, Stewart BM, Khanna C, Naramore R, Gordon IK   +5 more
core  

When Explant Surprises: Management and Outcomes of Hepatocellular Carcinoma Beyond Milan Criteria Discovered Post‐Transplant‐ A Narrative Review of Literature

Journal of Surgical Oncology, EarlyView.
ABSTRACT Liver transplantation (LT) is the definitive treatment for early hepatocellular carcinoma (HCC), based on established criteria. Pre‐transplant imaging occasionally underestimates the tumor burden or biological aggressiveness, leading to explant pathology that exceeds the projection criteria, such as Milan.
Serkan Sucu, Brian Longbottom, Hassan Aziz   +2 more
wiley   +1 more source