Cancer Research, 2021 This study identifies a EPHB2/β-catenin/TCF1 positive feedback loop that augments cancer stemness and sorafenib resistance in HCC, revealing a targetable axis to combat acquired drug resistance in HCC.
Hoi-Wing Leung +13 more
semanticscholar +1 more source
By inhibiting PFKFB3, aspirin overcomes sorafenib resistance in hepatocellular carcinoma [PDF]
International Journal of Cancer, 2017 Hepatocellular carcinoma (HCC) is one of the few cancers with a continuous increase in incidence and mortality. Drug resistance is a major problem in the treatment of HCC. In this study, two sorafenib‐resistant HCC cell lines and a nude mouse subcutaneously tumor model were used to explore the possible mechanisms leading to sorafenib resistance, and to
Sainan Li +18 more
openaire +2 more sources
TRERNA1 upregulation mediated by HBx promotes sorafenib resistance and cell proliferation in HCC via targeting NRAS by sponging miR-22-3p [PDF]
, 2021 Wei Song +11 more
openalex +1 more source
Incapacitated Capicua in Sorafenib-Resistant HCC [PDF]
Cellular and Molecular Gastroenterology and Hepatology, 2020 Dingzi Yin, PhD +1 more
openaire +3 more sources
Emerging role of the pentose phosphate pathway in hepatocellular carcinoma [PDF]
, 2017 In recent years, there has been a revival of interest in metabolic changes of cancer cells as it has been noticed that malignant transformation and metabolic reprogramming are closely intertwined.
Columbano, Amedeo +2 more
core +2 more sources
Label-retaining liver cancer cells are relatively resistant to sorafenib [PDF]
Gut, 2013 Objective The standard therapy for advanced hepatocellular carcinoma (HCC) is sorafenib, with most patients experiencing disease progression within 6 months. Label-retaining cancer cells (LRCC) represent a novel subpopulation of cancer stem cells (CSC).
Hong-Wu, Xin +17 more
openaire +2 more sources
Selective inhibition of FLT3 by gilteritinib in relapsed or refractory acute myeloid leukaemia: a multicentre, first-in-human, open-label, phase 1-2 study. [PDF]
, 2017 BackgroundInternal tandem duplication mutations in FLT3 are common in acute myeloid leukaemia and are associated with rapid relapse and short overall survival.
Altman, Jessica K +25 more
core +1 more source
TARBP2‐mediated destabilization of Nanog overcomes sorafenib resistance in hepatocellular carcinoma
Molecular Oncology, 2019 Hepatocellular carcinoma (HCC) is a lethal human malignancy and a leading cause of cancer‐related death worldwide. Patients with HCC are often diagnosed at an advanced stage, and the prognosis is usually poor.
Hui‐Huang Lai +6 more
doaj +1 more source
NEAT1–SOD2 Axis Confers Sorafenib and Lenvatinib Resistance by Activating AKT in Liver Cancer Cell Lines [PDF]
, 2023 Hiroyuki Tsuchiya +4 more
openalex +1 more source
Triple negative breast cancer: new perspectives for targeted therapies [PDF]
, 2015 Breast cancer is a heterogeneous disease, encompassing a large number of entities showing different morphological features and having clinical behaviors.
Caruso, Davide +8 more
core +1 more source