Results 91 to 100 of about 6,219 (205)
The Journal of Clinical Investigation, 2022 Genetic variants at the SORT1 locus in humans, which cause increased SORT1 expression in the liver, are significantly associated with reduced plasma levels of LDL cholesterol and apolipoprotein B (apoB).
Donna M. Conlon +6 more
doaj +1 more source
Molekulare Mechanismen der Sortilin-Regulation in der Gefäßkalzifizierung
, 2023 Patients with chronic kidney disease (CKD) have a four-fold increased cardiovascular risk compared to healthy subjects, resulting in clinical manifestations such as heart failure and myocardial infarction.
Himmelsbach, Anika
core
Sortilin expression in rat aortic smooth muscle cell populations.
, 2014 Representative blot analysis of (A) sortilin protein expression and transcript levels (B) in normal rat aortic medial tissue and 15 days after ballooning.
Ilana Moscatelli (505777) +5 more
core +1 more source
The Membrane Protein Sortilin Is a Potential Biomarker and Target for Glioblastoma
, 2023 Glioblastoma (GBM) is a devastating brain cancer with no effective treatment, and there is an urgent need for developing innovative biomarkers as well as therapeutic targets for better management of the disease. The membrane protein sortilin has recently
Hubert Hondermarck +8 more
core +1 more source
Editorial: Sortilin and Sortilin Partners in Physiology and Pathologies [PDF]
Frontiers in Pharmacology, 2019 Mazella, Jean +2 more
openaire +4 more sources
The role of sortilin in the “Glut4 Pathway”. [PDF]
Communicative & Integrative Biology, 2017 Sorting receptor, sortilin, is highly expressed in metabolically active tissues, such as brain, liver, skeletal muscle, and fat. Specifically in adipocytes, sortilin plays an important role in the “Glut4 pathway” by sorting the insulin-responsive glucose transporter, Glut4, in early endosomes and trans-Golgi network and re-routing the transporter from ...
openaire +2 more sources
Lysosomal targeting via the sortilin sorting receptor
, 2007 Delivery of soluble lysosomal proteins from the Golgi apparatus to the lysosomes is dependent primarily on the mannose 6-phosphate receptor (M6PR).
Canuel, Maryssa.
core
Sortilin and Its Multiple Roles in Cardiovascular and Metabolic Diseases
, 2018 Cardiovascular disease is a leading cause of morbidity and mortality in the Western world. Studies of sortilin’s influence on cardiovascular and metabolic diseases goes far beyond the genome-wide association studies that have revealed an association ...
Goettsch, Claudia +5 more
core +1 more source
徐州医科大学学报Objective To investigate the expression of cysteine-rich protein 61 (CYR61) and sortilin in peripheral blood of patients with diabetic lower extremity arterial disease (DLEAD) and their correlation with disease severity.
MA Yuting +3 more
doaj +1 more source
Altered Trek-1 Function in Sortilin Deficient Mice Results in Decreased Depressive-Like Behavior
Frontiers in Pharmacology, 2018 The background potassium channel TREK-1 has been shown to be a potent target for depression treatment. Indeed, deletion of this channel in mice resulted in a depression resistant phenotype.
Sébastien Moreno +5 more
doaj +1 more source