Results 71 to 80 of about 6,219 (205)
Endocrinology, Diabetes &Metabolism, Volume 9, Issue 5, September 2026.The primary function of statins is to inhibit cholesterol synthesis, which contributes to their antidiabetic effects. However, the majority of the diabetic effects of statins are due to inhibition of isoprenoid synthesis. Atorvastatin, simvastatin and rosuvastatin possess the most pronounced diabetogenic properties. In contrast, lovastatin, fluvastatin,
Ali Nosrati Andevari, Mohsen Koolivand
wiley +1 more source
Health Science Reports, Volume 9, Issue 9, September 2026.ABSTRACT Background and Aims Cardiovascular diseases (CVDs) remain the leading cause of global morbidity and mortality, encompassing coronary artery disease, hypertension, heart failure, and cerebrovascular disorders. The global burden of CVD continues to rise, driven by complex interactions among endothelial dysfunction, oxidative stress, inflammation,
Nawfal Hasan Siam +8 more
wiley +1 more source
A Quarter Century of EHD Protein Research: From Endosomal Recycling to Ciliopathies
Traffic, Volume 27, Issue 3, September 2026.Human EHD protein subcellular localization. ABSTRACT Eps15 homology domain‐containing proteins comprise a conserved family of membrane‐remodeling ATPases that regulate endocytic trafficking, membrane fission, receptor recycling, primary ciliogenesis and membrane dynamics across eukaryotes. Since the initial identification of EHD1 and its Caenorhabditis
Devin Frisby +3 more
wiley +1 more source
Scandinavian Journal of Pain, 2012 Abstract Background/aims The molecular mechanisms underlying neuropathic pain are incompletely understood, but recent data suggest that down-regulation of the chloride extruding co-transporter KCC2 in spinal cord sensory neurons is critical: Following peripheral nerve injury, activated ...
M. Richner +4 more
openaire +1 more source
Sortilin Regulates Progranulin Action in Castration-Resistant Prostate Cancer Cells [PDF]
, 2016 The growth factor progranulin is as an important regulator of transformation in several cellular systems. We have previously demonstrated that progranulin acts as an autocrine growth factor and stimulates motility, proliferation, and anchorage ...
Morcavallo, Alaide +13 more
core +1 more source
Scientific Reports, 2023 The selective transport to lysosomes can be mediated by either mannose-6-phosphate receptors (CD-MPR and CI-MPR) or sortilin. In mammalian epididymis, some lysosomal proteins are secreted into the lumen through unknown mechanisms.
Andrea Carolina Aguilera +7 more
doaj +1 more source
Traffic, Volume 27, Issue 3, September 2026.Clathrin plaques (magenta) form large, flat membrane‐associated lattices embedded within the cortical actin cytoskeleton, and can be distinguished from individual clathrin‐coated pits (yellow). These structures are surrounded by a dense network of actin filaments and associated proteins, illustrating the intimate structural coupling between clathrin ...
Marion Benoist, Stéphane Vassilopoulos
wiley +1 more source
Abstract 3327: Sortilin controls the EGFR nuclear translocation
, 2017 The epidermal growth factor receptor (EGFR) deregulations play a central role in cancer progression. EGFR generates extra- and intracellular signals through various pathways, including its release in the tumor microenvironment through extracellular ...
Hussein Al Akhrass +4 more
core +1 more source
A Plug‐and‐Play Platform for Customizing Multivalent Degraders and Degrader‐Drug Conjugates
Advanced Science, Volume 13, Issue 44, 7 August 2026.Membrane proteins remain challenging targets for conventional TPD approaches. Here, the authors develop UPTAB, a modular platform leveraging ultrahigh‐affinity orthogonal Im/CL protein pairs for lysosomal degradation of membrane proteins. Mono‐targeted (Type‐I), dual‐targeted (Type‐II), and tri‐targeted (Type‐III) UPTABs enable simultaneous degradation
Mengqing Zhao +7 more
wiley +1 more source
PLoS ONE, 2012 Prominent vasculopathy in Fabry disease patients is caused by excessive intracellular accumulation of globotriaosylceramide (GL-3) throughout the vascular endothelial cells causing progressive cerebrovascular, cardiac and renal impairments.
Thaneas Prabakaran +6 more
doaj +1 more source