Results 51 to 60 of about 6,219 (205)

Serum Sortilin Is Associated with Coronary Artery Calcification and Cardiovascular and Cerebrovascular Events in Maintenance Hemodialysis Patients

Kidney Diseases, 2021
Objective: To analyze the role of serum sortilin in coronary artery calcification (CAC) and cardiovascular and cerebrovascular events (CCE) in maintenance hemodialysis (MHD) patients.
Jie Xu, Chan-Juan Shen, Joshua D. Ooi, Yang-Shuo Tang, Zhou Xiao, Qiong-Jing Yuan, Yong Zhong, Qiao-Ling Zhou   +7 more
doaj   +1 more source

The Implications of Sortilin/Vps10p Domain Receptors in Neurological and Human Diseases

, 2014
International audienceThe neurotensin receptor-3 also known as sortilin is part of the new receptor family of vacuolar protein sorting 10 protein domain.
Wilson, C., Wilson, Cornelia, Pinet, S., Saada, S., Jauberteau, M., Naves, T., Lalloue, F., Naves, Thomas, Lalloué, Fabrice, Jauberteau, Marie-Odile, Saada, Sofiane, Pinet, Sandra, Vincent, François   +12 more
core   +1 more source

The Association Between Sortilin and Inflammation in Patients with Coronary Heart Disease

Journal of Inflammation Research, 2020
Wenxiu Han,1 Zhijie Wei,2 Hailiang Zhang,1 Chunmei Geng,1 Ruili Dang,1 Mengqi Yang,1 Jun Zhang,3 Changshui Wang,1 Pei Jiang1 1Department of Pharmacy, Jining First People’s Hospital, Jining Medical University, Jining 272011, People’s Republic ...
Han W, Wei Z, Zhang H, Geng C, Dang R, Yang M, Zhang J, Wang C, Jiang P   +8 more
doaj  

Neurotrophic Signaling, Sleep Physiology, and Retinal Neuroprotection: Integrative Mechanisms and Therapeutic Implications for Glaucoma

Sensory Neuroscience, EarlyView.
Glaucoma is increasingly understood as a neurodegenerative disorder shaped by sleep and circadian physiology, not intraocular pressure alone. Sleep loss and obstructive sleep apnea suppress BDNF–TrkB neurotrophic signaling, impair sleep‐dependent glymphatic clearance, and trigger microglial neuroinflammation and vascular insult at the optic nerve head,
Karyme M. Alemán‐Villa, Emiliano Terán, Javier A. Magaña‐Gómez, Loranda Calderón‐Zamora, Beatriz K. De la Herrán‐Arita, Alberto K. De la Herrán‐Arita   +5 more
wiley   +1 more source

Latozinemab, a novel progranulin-elevating therapy for frontotemporal dementia

Journal of Translational Medicine, 2023
Background Heterozygous loss-of-function mutations in the progranulin (PGRN) gene (GRN) cause a reduction in PGRN and lead to the development of frontotemporal dementia (FTD-GRN).
Michael Kurnellas, Ananya Mitra, Tina Schwabe, Robert Paul, Andrew E. Arrant, Erik D. Roberson, Michael Ward, Felix Yeh, Hua Long, Arnon Rosenthal   +9 more
doaj   +1 more source

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

Smart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin, Rui Peng, Guangshuai Zhang, Si Yan, Jin Xiao, Zishu Liu, Ziyu Tan, Qingqing Xie, Shangjie Li, Wei Luo, Xiaohe Xiao   +10 more
wiley   +1 more source

The enigmatic role of sortilin in lipoprotein metabolism [PDF]

Current Opinion in Lipidology, 2015
Sortilin, a multiple ligand sorting receptor, has emerged as a novel factor strongly associated with LDL cholesterol and atherosclerosis [1, 2]. Since VLDL is the precursor to LDL, hepatic VLDL metabolism becomes an important research focus. Results of manipulation of hepatic sortilin levels have been tabulated [1], and in general, a reciprocal ...
Charles E, Sparks, Robert P, Sparks, Janet D, Sparks   +2 more
openaire   +2 more sources

Sortilin mediates the release and transfer of exosomes in concert with two tyrosine kinase receptors.

, 2014
The transfer of exosomes containing both genetic and protein materials is necessary for the control of the cancer cell microenvironment to promote tumor angiogenesis.
Jauberteau, M., Naves, T., Lalloue, F., Melloni, B., Wilson, C., Vincent, F., Bonnaud, F.   +6 more
core   +1 more source

Impact of incretin analogues on lipid and lipoprotein metabolism in obesity and diabetes

British Journal of Pharmacology, EarlyView.
Abstract Incretin‐based therapies have gained momentum as a key strategy for reducing cardiovascular risk in individuals with obesity and/or type 2 diabetes (T2D). It remains unclear whether the cardiovascular benefits reflect a direct reduction in atherogenic lipoproteins—namely, low‐density lipoproteins (LDL), very low‐density lipoproteins (VLDL) and
Andrea Baragetti, Giuseppe Danilo Norata
wiley   +1 more source

Functional Organization of the Sortilin Vps10p Domain [PDF]

Journal of Biological Chemistry, 2004
A Vps10p domain makes up the entire luminal part of Sortilin, and this type of domain is the hallmark of a new family of neuronal receptors that target a variety of ligands, including neurotrophins and neuropeptides. We have shown that two structural features of the Vps10p domain, the N-terminal propeptide and the C-terminal segment of ten conserved ...
Uffe B, Westergaard, Esben S, Sørensen, Guido, Hermey, Morten S, Nielsen, Anders, Nykjaer, Kirstine, Kirkegaard, Christian, Jacobsen, Jørgen, Gliemann, Peder, Madsen, Claus Munck, Petersen   +9 more
openaire   +2 more sources