Results 31 to 40 of about 6,219 (205)
Oncotarget, 2015 The complexity and intricacy of nature has recently been illustrated with the role of sortilin in atherosclerosis. Sortilin, a VPS10p sorting receptor initially identified in human brain tissue, suddenly gained much attention from the cardiovascular community as unbiased genome-wide association studies (GWASs) repeatedly demonstrated that single ...
Mortensen, Martin B +2 more
openaire +3 more sources
Emerging roles of sortilin in affecting the metabolism of glucose and lipid profiles
Biomolecules & Biomedicine, 2022 Dyslipidemia has recently been identified as an important factor in modulating the progression of several health conditions, grouped as cardio-metabolic syndrome and including obesity,insulin resistance, and atherosclerosis. Among multiple factors which
Xin Su +4 more
doaj +1 more source
Sortilin levels are associated with peripheral arterial disease in type 2 diabetic subjects
Cardiovascular Diabetology, 2019 Background Sortilin is a 95-kDa protein which has recently been linked to circulating cholesterol concentration and lifetime risk of developing significant atherosclerotic disease.
Federico Biscetti +9 more
doaj +1 more source
A new role under sortilin's belt in cancer
Communicative & Integrative Biology, 2016 The neurotensin receptor-3 also known as sortilin was the first member of the small family of vacuolar protein sorting 10 protein domain (Vps10p) discovered two decades ago in the human brain.
Cornelia M. Wilson +7 more
doaj +1 more source
Tumor co-expression of progranulin and sortilin as a prognostic biomarker in breast cancer
BMC Cancer, 2021 Background The growth factor progranulin has been implicated in numerous biological processes such as wound healing, inflammation and progressive tumorigenesis.
Karoline Berger +8 more
doaj +1 more source
Frontiers in Aging Neuroscience, 2022 Extracellular β-amyloid (Aβ) deposition and intraneuronal phosphorylated-tau (pTau) accumulation are the hallmark lesions of Alzheimer’s disease (AD).
Juan Jiang +16 more
doaj +1 more source
Frontiers in Pharmacology, 2019 The molecular identification of sortilin, also called neurotensin receptor-3, from three different biochemical approaches already predicted the involvement of the protein in numerous biological and cellular functions.
Jean Mazella +2 more
doaj +1 more source
PLoS ONE, 2011 Progranulin haplo-insufficiency is a main cause of frontotemporal lobar degeneration (FTLD) with TDP-43 aggregates. Previous studies have shown that sortilin regulates progranulin trafficking and is a main determinant of progranulin level in the brain ...
Yanqiu Zheng +4 more
doaj +1 more source
Role of sortilin in the post-endocytic trafficking of thyroglobulin [PDF]
, 2009 Sortilin è una proteina di ~100 KDa appartenente alla famiglia delle proteine con dominio Vps10p. Sortilin è espressa da vari tipi cellulari, principalmente nel Golgi e negli endosomi, ed è coinvolta in diversi processi, tra cui l’endocitosi e il ...
BOTTA, ROBERTA
core +1 more source
Российский кардиологический журнал, 2022 Sortilin is an important molecular protein involved in lipid metabolism, atherosclerosis, and aortic valve calcification. Sortilin presumably regulates the PCSK9 signaling pathways.Aim.
Yu. Yu. Vukolova, I. V. Gubareva
doaj +1 more source