Results 21 to 30 of about 6,219 (205)
Absence of A Thyroid Phenotype in Sortilin-Deficient Mice
Endocrine Practice, 2015 The Vps10p family member sortilin is expressed in thyroid epithelial cells where it contributes to recycling of the thyroid hormone precursor thyroglobulin (Tg), a process that is thought to render hormone release more effective. Here we investigated the functional impact of sortilin in the thyroid gland using sortilin-deficient mice.We measured free ...
Lisi, Simonetta +7 more
openaire +4 more sources
Balancing neurotrophin pathway and sortilin function: its role in human disease [PDF]
, 2021 Neurotensin receptor-3 or sortilin is a vacuolar protein sorting 10 protein domain (Vps10p) has been firstly discovered in the human brain, it acts as receptor or co-receptor of the cell and traffics different proteins within the cell.
Liloglou, T. +4 more
core +1 more source
ApoE4 disrupts interaction of sortilin with fatty acid-binding protein 7 essential to promote lipid signaling [PDF]
, 2021 Sortilin is a neuronal receptor for apolipoprotein E. Sortilin-dependent uptake of lipidated apoE promotes conversion of polyunsaturated fatty acids (PUFA) into neuromodulators that induce anti-inflammatory gene expression in the brain.
Bakun, M. +24 more
core +1 more source
Circulation Research, 2015 Human genome-wide association studies have yielded a cornucopia of novel genetic loci that are associated with lipoprotein levels and coronary artery disease. However, a detailed understanding of the underlying mechanisms has for the majority proven elusive.
Marit, Westerterp, Alan R, Tall
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Circulation Research, 2011 Commentary on: From Noncoding Variant to Phenotype via SORT1 at the 1p13 Cholesterol Locus Musunuru et al. Nature . 2010;466:714–719 and Sort1, Encoded by the Cardiovascular Risk Locus 1p13.3, Is a Regulator of Hepatic Lipoprotein Export Kjolby et al. Cell Metab .
Alan R, Tall, Ding, Ai
openaire +2 more sources
Pro‐neurotrophins, sortilin, and nociception [PDF]
European Journal of Neuroscience, 2014 AbstractNerve growth factor (NGF) signaling is important in the development and functional maintenance of nociceptors, but it also plays a central role in initiating and sustaining heat and mechanical hyperalgesia following inflammation. NGF signaling in pain has traditionally been thought of as primarily engaging the classic high‐affinity receptor ...
Gary R. Lewin, Anders Nykjaer
openaire +4 more sources
Sortilin as a Regulator of Lipoprotein Metabolism [PDF]
Current Atherosclerosis Reports, 2012 Elevated low-density lipoprotein cholesterol (LDL-C) is associated with increased risk of atherosclerotic cardiovascular disease (ASCVD) and myocardial infarction (MI). Much of the insight into LDL metabolism has been gained through the study of Mendelian disorders of lipid metabolism.
Strong, Alanna, Rader, Daniel J.
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Frontiers in Cardiovascular Medicine, 2022 BackgroundSortilin, a protein that regulates glucose and lipid metabolism, has recently been linked to cardiovascular diseases (CVDs) such as coronary heart disease and carotid artery stenosis.
Xinglin Chu +6 more
doaj +1 more source
FEBS Open Bio, 2020 Post‐transcriptional regulation of cytokine production is crucial to ensure appropriate immune responses. We previously demonstrated that poly‐rC‐binding protein‐1 (PCBP1) can act as a trans‐acting factor to stabilize transcripts encoding sortilin, which
Toshiki Yabe‐Wada +2 more
doaj +1 more source
Journal of Lipid Research, 2022 Elevated plasma lipoprotein(a) (Lp(a)) is an independent, causal risk factor for atherosclerotic cardiovascular disease and calcific aortic valve stenosis. Lp(a) is formed in or on hepatocytes from successive noncovalent and covalent interactions between
Justin R. Clark +8 more
doaj +1 more source