Results 11 to 20 of about 6,219 (205)
Current Opinion in Nephrology & Hypertension, 2022 Purpose of review The current review aims to present the latest scientific updates on the role of Sortilin in the pathophysiology of hypertension. Recent findings The main focus of this systematic overview is on the functional contribution of Sortilin to the pathogenesis of ...
Avvisato, Roberta +5 more
openaire +4 more sources
Sortilin Is a Putative Postendocytic Receptor of Thyroglobulin [PDF]
Endocrinology, 2008 The Vps10p family member sortilin is involved in various cell processes, including protein trafficking. Here we found that sortilin is expressed in thyroid epithelial cells (thyrocytes) in a TSH-dependent manner, that the hormone precursor thyroglobulin (Tg) is a high-affinity sortilin ligand, and that binding to sortilin occurs after Tg endocytosis ...
BOTTA, ROBERTO +15 more
core +7 more sources
Prions amplify through degradation of the VPS10P sorting receptor sortilin. [PDF]
PLoS Pathogens, 2017 Prion diseases are a group of fatal neurodegenerative disorders caused by prions, which consist mainly of the abnormally folded isoform of prion protein, PrPSc.
Keiji Uchiyama +7 more
doaj +3 more sources
Sortilin in Glucose Homeostasis: From Accessory Protein to Key Player? [PDF]
Frontiers in Pharmacology, 2019 The pharmacological properties and physiological roles of the type I receptor sortilin, also called neurotensin receptor-3, are various and complex.
Nicolas Blondeau +4 more
doaj +2 more sources
Role of Sortilin in Models of Autoimmune Neuroinflammation [PDF]
The Journal of Immunology, 2015 Abstract The proneurotrophin receptor sortilin is a protein with dual functions, being involved in intracellular protein transport, as well as cellular signal transduction. The relevance of the receptor for various neuronal disorders, such as dementia, seizures, and brain injury, is well established.
Eva Reuter +8 more
openaire +6 more sources
Toxoplasma sortilin interacts with secretory proteins and it is critical for parasite proliferation
Parasites & VectorsBackground The human sortilin protein is an important drug target and detection marker for cancer research. The sortilin from Toxoplasma gondii transports proteins associated with the apical organelles of the parasite.
Chenghuan Li +7 more
doaj +2 more sources
Sortilin regulates blood–brain barrier integrity [PDF]
The FEBS Journal, 2021 Brain homeostasis depends on the existence of the blood–brain barrier (BBB). Despite decades of research, the factors and signalling pathways for modulating and maintaining BBB integrity are not fully elucidated. Here, we characterise the expression and function of the multifunctional receptor, sortilin, in the cells of the BBB,
Toth, Andrea E. +15 more
openaire +5 more sources
Sortilin inhibition limits secretion-induced progranulin-dependent breast cancer progression and cancer stem cell expansion [PDF]
Breast Cancer Research, 2018 Background Cancer progression is influenced by genetic aberrations in the cancer cell population as well as by other factors including the microenvironment present within a tumour.
Sara Rhost +11 more
doaj +2 more sources
Sortilin participates in light-dependent photoreceptor degeneration in vivo. [PDF]
PLoS ONE, 2012 Both proNGF and the neurotrophin receptor p75 (p75(NTR)) are known to regulate photoreceptor cell death caused by exposure of albino mice to intense illumination.
Ana M Santos +5 more
doaj +2 more sources
Sortilin Fragments Deposit at Senile Plaques in Human Cerebrum [PDF]
Frontiers in Neuroanatomy, 2017 Genetic variations in the vacuolar protein sorting 10 protein (Vps10p) family have been linked to Alzheimer’s disease (AD). Here we demonstrate deposition of fragments from the Vps10p member sortilin at senile plaques (SPs) in aged and AD human cerebrum.
Xia Hu +17 more
doaj +2 more sources