Results 1 to 10 of about 6,219 (205)

Molecular recognition of thyroglobulin by sortilin [PDF]

Nature Communications
Sortilin is a ubiquitous membrane receptor mediating trafficking of protein cargoes. In the thyroid, sortilin binds thyroglobulin (TG) during its endocytosis, a key process in thyroid homeostasis.
Irene Boniardi, Giorgia Tanzi, Alessio Di Ianni, Andrea Graziadei, Marko Nedeljković, Camilla Stejskalova, Francesca Coscia   +6 more
doaj   +9 more sources

An anti-sortilin affibody-peptide fusion inhibits sortilin-mediated progranulin degradation

Frontiers in Immunology
Heterozygous loss-of-function mutations in the GRN gene are a common cause of frontotemporal dementia. Such mutations lead to decreased plasma and cerebrospinal fluid levels of progranulin (PGRN), a neurotrophic factor with lysosomal functions.
John Löfblom, Johan Nilvebrant, Per-Åke Nygren   +2 more
exaly   +6 more sources

Sortilin as a Biomarker for Cardiovascular Disease Revisited [PDF]

Frontiers in Cardiovascular Medicine, 2021
Genetic variants in the genomic region containing SORT1 (encoding the protein sortilin) are strongly associated with cholesterol levels and the risk of coronary artery disease (CAD).
Peter Loof Møller, Palle D. Rohde, Simon Winther, Peter Breining, Peter Breining, Louise Nissen, Anders Nykjaer, Anders Nykjaer, Morten Bøttcher, Mette Nyegaard, Mette Nyegaard, Mads Kjolby, Mads Kjolby, Mads Kjolby, Mads Kjolby   +14 more
doaj   +8 more sources

Elevated serum sortilin reflects inflammatory burden and coagulation dysfunction in ulcerative colitis [PDF]

Frontiers in Medicine
BackgroundSortilin, a multifunctional receptor, is implicated in inflammatory signaling; however, its clinical significance in ulcerative colitis (UC) remains unclear.
Jiangtao Ding, Haizhou Xu
doaj   +2 more sources

Targeting the ASMase/S1P pathway protects from sortilin-evoked vascular damage in hypertension [PDF]

The Journal of Clinical Investigation, 2022
Sortilin has been positively correlated with vascular disorders in humans. No study has yet evaluated the possible direct effect of sortilin on vascular function.
Paola Di Pietro, Albino Carrizzo, Eduardo Sommella, Marco Oliveti, Licia Iacoviello, Augusto Di Castelnuovo, Fausto Acernese, Antonio Damato, Massimiliano De Lucia, Fabrizio Merciai, Paola Iesu, Eleonora Venturini, Raffaele Izzo, Valentina Trimarco, Michele Ciccarelli, Giuseppe Giugliano, Roberto Carnevale, Vittoria Cammisotto, Serena Migliarino, Nicola Virtuoso, Andrea Strianese, Viviana Izzo, Pietro Campiglia, Elena Ciaglia, Bodo Levkau, Annibale A. Puca, Carmine Vecchione   +26 more
doaj   +2 more sources

Evaluating maternal serum sortilin levels: a potential biomarker for predicting preeclampsia [PDF]

BMC Pregnancy and Childbirth
Objective To determine the role of sortilin in the pathogenesis of preeclampsia by examining serum sortilin levels in maternal blood. Methods This prospective case-control study was conducted from May to November 2023 at the Perinatology Clinic of Ankara
Gulsan Karabay, Burak Bayraktar, Zeynep Seyhanli, Betul Tokgoz Cakir, Gizem Aktemur, Serap Topkara Sucu, Nazan Vanli Tonyali, Umut Karabay, Dilara Kurt, Ali Turhan Caglar   +9 more
doaj   +2 more sources

CIMT as a sensitive indicator of cardiovascular risk in PCOS: a case–control study of sortilin and sclerostin [PDF]

BMC Women's Health
Background Polycystic ovary syndrome (PCOS) is associated with increased cardiometabolic risk, and subclinical vascular damage can be evaluated using carotid intima–media thickness (CIMT) and arterial stiffness measures such as pulse wave velocity (PWV).
Hatice Çalışkan Burgucu, Zeliha Yarar, Mustafa Can, Yusuf Karadeni̇z, Fatma Hümeyra Yerlikaya Aydemi̇r, Melia Karaköse, Mustafa Kulaksızoğlu, Feridun Karakurt   +7 more
doaj   +2 more sources

High-frequency repetitive transcranial magnetic stimulation protects against 6-OHDA-induced Parkinson’s disease symptoms by modulating the proNGF-p75NTR-sortilin pathway [PDF]

PeerJ
Background High-frequency repetitive transcranial magnetic stimulation (HF rTMS) is a promising non-invasive treatment for Parkinson’s disease (PD) in clinical settings. However, the precise mechanisms are incompletely understood.
Rui Zhao, Wanqing Du, Ke Tian, Kunlong Zhang, Hua Yuan, Fang Gao, Xin Kang, Xiaolong Sun   +7 more
doaj   +3 more sources

Development of AL101 (GSK4527226), a progranulin-elevating monoclonal antibody, as a potential treatment for Alzheimer’s disease [PDF]

Alzheimer’s Research & Therapy
Background Alzheimer’s disease (AD) is characterized by amyloid plaques, tau tangles, and neuronal loss. Progranulin (PGRN) is a secreted immune regulator, lysosomal chaperone, and neuronal survival factor.
Balasubrahmanyam Budda, Ananya Mitra, Lovingly Park, Hua Long, Michael Kurnellas, Nga Bien-Ly, William Estacio, Brady Burgess, Grace Chao, Tina Schwabe, Robert Paul, Sara Kenkare-Mitra, Arnon Rosenthal   +12 more
doaj   +2 more sources

Sorting through the extensive and confusing roles of sortilin in metabolic disease

Journal of Lipid Research, 2022
Sortilin is a post-Golgi trafficking receptor homologous to the yeast vacuolar protein sorting receptor 10 (VPS10). The VPS10 motif on sortilin is a 10-bladed β-propeller structure capable of binding more than 50 proteins, covering a wide range of ...
Kelly A. Mitok, Mark P. Keller, Alan D. Attie   +2 more
doaj   +1 more source