Results 61 to 70 of about 6,219 (205)
PLoS ONE, 2014 BackgroundSortilin, a member of the Vps10p-domain receptor family, has been demonstrated a key regulator in mediating cellular response to pro-neurotrophins.
Luisa Campagnolo +5 more
doaj +1 more source
Presenilin1 inhibits glioblastoma cell invasiveness via promoting Sortilin cleavage
Cell Communication and Signaling, 2021 Background Alzheimer’s disease (AD) and glioblastoma are the most common and devastating diseases in the neurology and neurosurgery departments, respectively.
Wei Yang +8 more
doaj +1 more source
Cancer Science, EarlyView.Targeted triggering of SORL1 expression through a novel MPOC delivery system could inhibit ccRCC progression through binding to TRIM22 and further promoting ubiquitination‐mediated C‐MYC degradation, thereby facilitating the inhibition of oxidative phosphorylation through transcriptional repression of ACO2 and IDH2.
Keyi Wang +11 more
wiley +1 more source
Sortilin and lipoprotein metabolism [PDF]
Current Opinion in Lipidology, 2014 Genome-wide association studies have been used as an unbiased tool to identify novel genes that contribute to variations in LDL cholesterol levels in the hopes of uncovering new biology and new therapeutic targets for the treatment of atherosclerotic cardiovascular disease.
Alanna, Strong +2 more
openaire +2 more sources
Biomarkers Correlating With the Development of Oral Squamous Cell Carcinoma From Leukoplakia
Oral Diseases, EarlyView.ABSTRACT Background We assessed protein biomarkers expressed in oral leukoplakia (OL) that are associated with the risk of transformation into oral squamous cell carcinoma (OSCC). Methods Tissue sections of OL transforming into OSCC (leuko‐ca), the corresponding OSCC and OL that did not progress to OSCC (leuko‐nonca) were analyzed with global relative ...
Daniel Giglio +8 more
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 19, Page 5791-5812, October 2026.Ischaemic stroke is characterised by acute cerebrovascular occlusion and blood–brain barrier (BBB) breakdown. Our results indicated that the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) ameliorated the loss of BBB integrity, changed the morphology of brain endothelial cells, increased the level of basement membrane and ...
Anikó Szecskó +14 more
wiley +1 more source
The Journal of Clinical Investigation, 2022 Sortilin is a glycoprotein mainly known for its role as a trafficking molecule directing proteins to specific secretory or endocytic compartments of the cell. Its actual contribution to essential hypertension has remained hitherto elusive.
Fahimeh Varzideh +5 more
doaj +1 more source
The Alzheimer's disease risk gene SORL1 is a regulator of excitatory neuronal function
Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.Abstract INTRODUCTION Synaptic dysfunction is an early feature of Alzheimer's disease (AD) and proper localization of proteins involved in pre‐ and post‐synaptic composition is dependent on endosomal recycling and trafficking, cellular processes involving the AD risk gene sortilin‐related receptor 1 (SORL1). METHODS We examined SORL1's role in synaptic
C. Andrew Williams +6 more
wiley +1 more source
PLoS ONE, 2013 The processing of Amyloid precursor protein (APP) is multifaceted, comprising of protein transport, internalization and sequential proteolysis. However, the exact mechanism of APP intracellular trafficking and distribution remains unclear.
Miao Yang +9 more
doaj +1 more source
Sortilin is associated with the chlamydial inclusion and is modulated during infection
Biology Open, 2016 Chlamydia species are obligate intracellular pathogens that have a major impact on human health. The pathogen replicates within an intracellular niche called an inclusion and is thought to rely heavily on host-derived proteins and lipids, including ...
Wei Xuan Teo +3 more
doaj +1 more source