Results 81 to 90 of about 6,219 (205)

The past, the present, and the future of preclinical mouse models for Alzheimer's disease and related dementias

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract Over the past decade, the Model Organism Development and Evaluation for Late‐Onset Alzheimer's Disease (MODEL‐AD) consortium has transformed preclinical Alzheimer's disease (AD) research by addressing critical limitations in traditional mouse models that failed to translate to human disease.
Adrian L. Oblak, Michael Sasner, Gregory W. Carter, Gareth R. Howell, Stacey J. Sukoff Rizzo, Karina Leal, Paul R. Territo, Bruce T. Lamb   +7 more
wiley   +1 more source

Sortilin expression by CRC cell lines.

, 2013
(A) Sortilin detection by RT-PCR of total RNA extracted from cells cultured in 10% FCS and after 24–72 h serum starvation. Expression was controlled with specific primers for its extracellular (Sortilin EC) and intracellular (Sortilin IC) parts.
Hussein Akil (343344), Carole Mélin (343346), Aurélie Perraud (343345), Muriel Mathonnet (343347), Marie-Odile Jauberteau (340223)   +4 more
core   +1 more source

Aberrant ɑSMA expression reveals broad mossy fiber reorganization integrating with tangle and plaque formation and mitoenergetic alteration in the human hippocampus

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Neural network and bioenergetic abnormalities occur with Alzheimer's disease (AD) pathogenesis. METHODS We explored mossy fiber (MF) and mitoenergetic alteration using ɑ‐smooth muscle actin (ɑSMA) and cytochrome c oxidase (COX) immunolabeling in human hippocampus relative to tangle and plaque formation by referring to Braak (0–VI)
Tian Tu, Qi‐Lei Zhang, Zhong‐Ping Sun, Chao Kang, Dan Li, Xin‐Hua Huo, Xiao‐Jie Zhang, Yan Zhang, Mengchao Cui, Aihua Pan, Jian Wang, Xiao‐Xin Yan   +11 more
wiley   +1 more source

Binding of α-Gal A by M6PR and sortilin.

, 2013
The purified ectodomains of M6PR and sortilin were immobilized on BIAcore chips. (A) SPR analysis of α-Gal A binding to purified human M6PR. (B) Binding of 50 nM α-Gal A to M6PR in the presence or absence of 50 µM M6P.
Ulla Feldt-Rasmussen (317604), Simon C. Satchell (140614), Søren S. Sørensen (317606), Rikke Nielsen (317601), Erik I. Christensen (317608), Thaneas Prabakaran (317599), Peter W. Mathieson (162070)   +6 more
core   +1 more source

SORL1 variant links endosomal amyloid precursor protein mis‐sorting to axonal transport defects and neuronal dysfunction

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION SORL1 encodes the sorting receptor SORLA, a major genetic contributor to Alzheimer's disease (AD). Although SORL1 loss disrupts endosomal trafficking and promotes amyloidogenic amyloid precursor protein (APP) processing, the functional consequences of specific missense variants in human neurons remain unclear.
Miriam Lep, Klara Plesingrova, Jiri Sedmik, Sona Cesnarikova, Monica Feole, Ondrej Bernatik, Victorio Martin Pozo Devoto, Hana Hribkova, Katerina Amruz Cerna, Petr Fojtik, Nadezda Vaskovicova, Simona Bartova, Veronika Pospisilova, Tereza Vanova, Olav Michael Andersen, Dasa Bohaciakova, Jan Raska   +16 more
wiley   +1 more source

Microenvironmental control of sortilin exosomes in lung cancer

, 2019
Lung cancer, despite medical advancement, is still the most common form of cancer, and contributes to the highest incidence rate of mortality of all cancer types.
Woodman, C.
core  

Clinical Significance and Changes in Levels of Serum BDNF, mBDNF, AQP4, proBDNF, and GSK3β in Individuals Diagnosed With Bipolar Disorder: A Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background and Aims Bipolar disorder (BD) is a severe mood disorder with unclear pathogenesis and limited diagnostic biomarkers. This study aimed to evaluate serum levels of BDNF, mBDNF, AQP4, proBDNF, and GSK3β between BD patients and healthy controls, and to preliminarily explore their potential clinical significance.
Jiawei Zhou, Chunying Zhu, Juezhuo Li, Lailing Du, Jinghua Yuan, Kewei Tian, Xinling Zhang, Xiaoping Li   +7 more
wiley   +1 more source

Regulatory Roles of Sortilin and SorLA in Immune-Related Processes

Frontiers in Pharmacology, 2019
Sortilin, also known as Neurotensin Receptor-3, and the sorting-related receptor with type-A repeats (SorLA) are both members of the Vps10p domain receptor family.
Hugo Talbot, Sofiane Saada, Thomas Naves, Paul-François Gallet, Anne-Laure Fauchais, Anne-Laure Fauchais, Marie-Odile Jauberteau, Marie-Odile Jauberteau   +7 more
doaj   +1 more source

Immunometabolic Dysregulation in Obesity: Integrating Macrophage Polarization, Metabolic Reprogramming, and Gut Microbiota Crosstalk

Immunity, Inflammation and Disease, Volume 14, Issue 8, August 2026.
ABSTRACT Background Obesity is characterized by chronic low‐grade systemic inflammation, in which adipose tissue macrophages (ATMs) play a pivotal role in driving immune and metabolic dysfunction. Objective This review summarizes current evidence on the roles of ATMs in obese adipose tissue and examines how macrophage polarization and metabolic ...
Yuanyuan Li, Jingwei Mao, Yiwen Deng, Xiaobo Ge, Limin Nie, Qun Wang, Ruiqing Wang, Jiarun Zhang, Tianli Lyu, Luopeng Zhao, Lu Liu, Bin Li   +11 more
wiley   +1 more source

Sortilin mediates the release and transfer of exosomes in concert with two tyrosine kinase receptors

, 2015
Introduction: Cancer cells can influence their cellular microenvironment through intercellular communication. Growing evidence indicates that microenvironment control is supported by the release of extracellular microvesicles, called exosomes.
Jauberteau, M., Naves, T., Lalloue, F., Wilson, C., Vincent, F.   +4 more
core