Results 71 to 80 of about 1,214,310 (343)
Membrane Mediated Sorting [PDF]
Physical Review Letters, 2010 Inclusions in biological membranes may interact via deformations they induce on the shape of that very membrane. Such deformations are a purely physical effect, resulting in nonspecific forces between the inclusions. In this Letter we show that this type of interaction can organize membrane domains and hence may play an important biological role. Using
Idema, T. +3 more
openaire +2 more sources
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Operators of equivalent sorting power and related Wilf-equivalences [PDF]
Discrete Mathematics & Theoretical Computer Science, 2013 We study sorting operators $\textrm{A}$ on permutations that are obtained composing Knuth's stack sorting operator \textrmS and the reverse operator $\textrm{R}$, as many times as desired.
Michael Albert, Mathilde Bouvel
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Studia Universitatis Babes-Bolyai Sociologia, 2018 Lefebvre’s 1970 prophecy of the total urbanisation of society has come true with the expansion of the urban into natural and rural territories. For Lefebvre, the question of nature is closed by its ‘steady, violent death’ (Lefebvre, 2003) and its ...
Hurducaş Iulia
doaj +1 more source
Protein secretion: Sorting sweet sorting [PDF]
Current Biology, 1996 AbstractMembrane-spanning, lectin-like proteins in the eukaryotic secretory pathway seem to operate quality-control checkpoints by fine tuning protein exit or retention within each subcompartment.
Ponnambalam, Sreenivasan +1 more
openaire +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Cryo-Ability of Boar Sperm sorted by Percoll Containing of Antioxidative Enzyme
Journal of Animal Reproduction and Biotechnology, 2015 The objective of this study was to evaluate the efficiency of sperm cryosurvival in boar sperm separated by Percoll containing antioxidant enzymes.
Kyung-Jin Lee +10 more
doaj +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source