Clinical Features of Cellular Senescence Pathways in Severe Asthma
Allergy, EarlyView.In bronchial biopsies, SASP and p53 pathway enrichment scores are elevated in severe asthma versus non‐severe asthma and healthy controls. SASP enrichment is validated in the independent NOVA cohort. SASP enrichment is also elevated in nasal brushings of participants with nasal polyps, independently of asthma status.
Woo‐Jung Song +122 more
wiley +1 more source
Transformation of the Agrarian Landscape and Hope in the Central Kalimantan Peatlands
Asia Pacific Viewpoint, EarlyView.ABSTRACT In Kalimantan, Indonesian Borneo, agrarian state programs and corporate strategies seek to transform indigenous Ngaju Dayak into sedentary farmers. Focusing on the notion of transformation, the paper traces whether and how rural people can engage in struggles against structural injustices.
Anu Lounela
wiley +1 more source
Effect of a Defective Clamp Loader Complex of DNA Polymerase III on Growth and SOS Response in Pseudomonas aeruginosa. [PDF]
Microorganisms, 2022 Spinnato MC +7 more
europepmc +1 more source
Cardiotoxicity of BRAF/MEK inhibitors
British Journal of Pharmacology, EarlyView.Abstract Rapidly accelerated fibrosarcoma type B/B‐Raf proto‐oncogene, serine/threonine kinase (BRAF) and mitogen‐activated protein kinase (MEK) inhibitors have transformed outcomes in cancer therapy, particularly in melanoma. However, cardiovascular toxicities are increasingly recognized in real‐world clinical practice.
Katharina Seuthe +4 more
wiley +1 more source
Psychoactive Drugs Induce the SOS Response and Shiga Toxin Production in Escherichia coli. [PDF]
Toxins (Basel), 2021 Crane JK, Salehi M, Alvarado CL.
europepmc +1 more source
Functional screen for subtype specificity of voltage sensor–targeted Kv7 potentiators
British Journal of Pharmacology, EarlyView.Background and Purpose Voltage‐gated Kv7 (potassium channel subfamily Q [KCNQ]) potassium channels are powerful modulators of neuronal excitability. ICA‐069673 is a N‐aryl benzamide drug that targets the voltage‐sensing domain (VSD) of Kv7.2 with strong selectivity over Kv7.3 or Kv7.5, but the molecular basis of this selectivity remains poorly ...
Richard Kanyo +6 more
wiley +1 more source
Strain-Specific Gifsy-1 Prophage Genes Are Determinants for Expression of the RNA Repair Operon during the SOS Response in Salmonella enterica Serovar Typhimurium. [PDF]
J Bacteriol, 2023 Kurasz JE +8 more
europepmc +1 more source
Adherence to Treatment in Allergic Rhinitis During the Pollen Season in Europe: A MASK‐air Study
Clinical &Experimental Allergy, Volume 55, Issue 3, Page 226-238, March 2025.In a study assessing mobile health data, (i) adherence to rhinitis medication was highest for oral antihistamines and lowest for azelastine‐fluticasone, (ii) in weeks of partial adherence, azelastine‐fluticasone was associated with lower levels of reported rhinitis symptoms than other medication classes.
Bernardo Sousa‐Pinto +121 more
wiley +1 more source
The Regulation of LexA on UV-Induced SOS Response in Myxococcus xanthus Based on Transcriptome Analysis. [PDF]
J Microbiol Biotechnol, 2021 Sheng DH, Wang Y, Wu SG, Duan RQ, Li YZ.
europepmc +1 more source
Child &Family Social Work, EarlyView.ABSTRACT This article presents a methodological study examining how inclusive, visually supported workshops can facilitate the participation of children with disabilities in research on family life. The study demonstrates how the combined use of visual structuring, sensory‐aware pacing and relational scaffolding can expand communicative possibilities ...
Cecilie K. Moesby‐Jensen +1 more
wiley +1 more source