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Genetics of Sost/SOST in sclerosteosis and van Buchem disease animal models [PDF]
Metabolism: Clinical and Experimental, 2018 Sclerosteosis and van Buchem disease (VBD) are two rare autosomal recessive disorders that results from osteoblast hyperactivity, in which progressive bone overgrowth leads to very dense bones, distortion of the face, and entrapment of cranial nerves.
Gabriela Loots, Aimy Sebastian
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Reversing LRP 5-Dependent Osteoporosis and SOST Deficiency–Induced Sclerosing Bone Disorders by Altering WNT Signaling Activity [PDF]
Journal of Bone and Mineral Research, 2014 The bone formation inhibitor sclerostin encoded by SOST binds in vitro to low-density lipoprotein receptor-related protein (LRP) 5/6 Wnt co-receptors, thereby inhibiting Wnt/β-catenin signaling, a central pathway of skeletal homeostasis.
Jonathan Gooi, Hansjoerg Keller
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SOST/Sclerostin Improves Posttraumatic Osteoarthritis and Inhibits MMP2/3 Expression After Injury [PDF]
Journal of Bone and Mineral Research, 2018 Patients with anterior cruciate ligament (ACL) rupture are two times as likely to develop posttraumatic osteoarthritis (PTOA). Annually, there are ∼900,000 knee injuries in the United States, which account for ∼12% of all osteoarthritis (OA) cases.
Gabriela Loots +2 more
exaly +3 more sources
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Expression and regulation of the SOST gene
Yi Chuan = Hereditas / Zhongguo Yi Chuan Xue Hui Bian Ji, 2013Qing-Yang Huang
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Epigenetic Regulation of Sost/sclerostin Expression
Current Molecular Biology Reports, 2017Sclerostin, encoded by the gene Sost, is a regulatory glycoprotein produced by mature osteocytes in bone. Findings in animals and humans revealed that Sost/sclerostin deficiency results in increased bone density, and neutralizing antibodies to this protein are being investigated for treatment of postmenopausal osteoporosis.
Alvaro DEL REAL +2 more
exaly +2 more sources
The effects of SOST on implant osseointegration in ovariectomy osteoporotic mice
Archives of Oral Biology, 2017Osteoporosis is a risk factor for implant fixation failure. The inhibition of sclerostin effectively improves bone formation and bone remodeling. Therefore, this study investigated whether SOST deficiency enhances the osseointegration of implants in a mouse model of osteoporosis induced by ovariectomy (OVX).Osteoporosis was induced in female C57BL/6 ...
Rui, Shu +5 more
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A comparison of SOST and HVDC transient simulation algorithms
Digest of INTERMAG 2003. International Magnetics Conference (Cat. No.03CH37401), 2004In this paper, detailed simulation of HVDC converter behavior has been modified to include automatic selection of optimal integration steps, frequency-dependent effects of AC system, AC system phase and magnitude dynamics of voltage (particularly weak systems), control assessment and temporary over voltage consequences and root-matching techniques (for
Z. Zangeneh-Baktiar, null Shoulaie-Abbas
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[Expression and regulation of the SOST gene].
Yi chuan = Hereditas, 2016Sclerostin(SOST), mainly expressed in osteocytes, is a negative regulator of bone formation. Hormones PTH and E2 inhibit the expression of the SOST gene. Transcription factors Osterix, Runx2, and Mef2c promote the SOST expression, while Sirt1 negatively regulates the SOST expression.
Long-Juan, Qin +3 more
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SOST/sclerostin, an osteocyte-derived negative regulator of bone formation
Cytokine & Growth Factor Reviews, 2005Sclerosteosis and Van Buchem disease are two closely related bone disorders characterized by progressive bone thickening due to increased bone formation. Sclerosteosis is associated with mutations in the SOST gene and Van Buchem disease with a 52 kb deletion downstream of the SOST gene that probably affects transcription of the gene.
Rutger L, van Bezooijen +3 more
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