Results 51 to 60 of about 59,986 (306)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Esfuerzo fiscal de las entidades federativas mexicanas durante el periodo 2004 al 2012
Economía Teoría y Práctica, 2017 No obstante que la dependencia financiera de los gobiernos municipales hacia el gobierno federal es un problema persistente, poco se ha estudiado el esfuerzo fiscal a nivel estatal en México con evidencia de los últimos años.
Delia Laura Sour Vargas
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Journal of Central and Eastern European African StudiesTerrorism is not new to Algeria, it had a long history, which dating back to the early 80'. In fact, Islamic extremism in Algeria have indeed existed before the cancellation of the electoral process at the beginning of 1992. Following a series of deadly
Lotfi SOUR
doaj +1 more source
E-Government and Corruption in Mexico (2005-2010)
Innovar: Revista de Ciencias Administrativas y Sociales, 2017 Several studies prove that e-government is a tool that facilitates transactions and the exchange of information digitally between the public administration and citizens, minimizing the probability of corrupt acts.
Delia Laura Sour Vargas
doaj +1 more source
pHirst sour taste channels pHound? [PDF]
, 2018 Newly discovered acid channels may finally resolve the sour taste reception ...
Craig Montell, Montell, Craig
core +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source