Results 121 to 130 of about 7,549,002 (298)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
The usability of open source software: analysis and prospects [PDF]
, 2006 Open source communities have successfully developed many pieces of software although most computer users only use proprietary applications. The usability of open source software is often regarded as one reason for this limited distribution. In this paper
Nichols, David M., Twidale, Michael B.
core
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Source-Data-Free Cross-Domain Knowledge Transfer for Semantic Segmentation
This article proposes a method for transferring knowledge of semantic segmentation from a labeled source domain to an unlabeled target domain without using the source-domain data.
Zongyao Li +3 more
core +1 more source
Combining multi-domain statistical machine translation models using automatic classifiers [PDF]
, 2010 This paper presents a set of experiments on Domain Adaptation of Statistical Machine Translation systems. The experiments focus on Chinese-English and two domain-specific corpora. The paper presents a novel approach for combining multiple domain-trained
Li, Baoli +5 more
core +2 more sources
Laughing with a Message: The Subtle Power of Cartoons in Ghana’s Public Discourse and Communication
ArtsThis study investigates the communicative power of editorial cartoons in Ghana’s public discourse, focusing on how they inform, critique, and influence sociopolitical narratives.
Alexander Angsongna
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
, 2023 From a service perspective, Multi-Source Domain Adaptation (MSDA) is a promising scenario to adapt a deployed model to a client's dataset. It can provide adaptation without a target label and support the case where a source dataset is constructed from ...
Yang, Eunju +2 more
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