Results 141 to 150 of about 7,549,002 (298)

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

open access: yesMolecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler   +3 more
wiley   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

DMSD-CDFSAR: Distillation from Mixed-Source Domain for Cross-Domain Few-shot Action Recognition [PDF]

open access: yes
Few-shot action recognition is an emerging field in computer vision, primarily focused on meta-learning within the same domain. However, challenges arise in real-world scenario deployment, as gathering extensive labeled data within a specific domain is ...
Wang, YiKang   +4 more
core   +1 more source

Conceptual Metaphors in Narrative Advertisements for Places: A Comparative Study Between English and Lithuanian

open access: yesNalans
The paper examines 15 conceptual metaphors in advertisements for hotels based in Lithuania, focusing on the similarities and differences between English and Lithuanian versions of these advertisements.
Linas Selmistraitis   +2 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso   +5 more
wiley   +1 more source

Quantitative unraveling of spinodal decomposition in Cu-15Ni-8Sn alloys via small-angle neutron scattering: Kinetics and strengthening mechanisms

open access: yesMaterials & Design
Cu-Ni-Sn alloys are widely used in electrical and other fields owing to their excellent mechanical properties. Spinodal decomposition (SD) plays a critical role in strengthening these alloys.
Shunfu Xie   +8 more
doaj   +1 more source

Home - About - Disclaimer - Privacy