Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Source-Free Domain Adaptation with Diffusion-Guided Source Data Generation [PDF]
This paper introduces a novel approach to leverage the generalizability of Diffusion Models for Source-Free Domain Adaptation (DM-SFDA). Our proposed DMSFDA method involves fine-tuning a pre-trained text-to-image diffusion model to generate source domain
Chopra, Shivang +3 more
core +1 more source
A brain-like classification method for computed tomography images based on adaptive feature matching dual-source domain heterogeneous transfer learning. [PDF]
Front Hum Neurosci, 2022 Chen Y, Chen X.
europepmc +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Human Source Domain in Metaphorizing Corporate Terminology
Cognitive Studies | Études cognitivesThis study attempts to apply the theory of conceptual metaphor to investigate the cognitive mechanism of metaphorisation in corporate terminology mapped from the human source domain.
Nguyen Thi Thuy Hanh
doaj +1 more source
Partial Transfer Ensemble Learning Framework: A Method for Intelligent Diagnosis of Rotating Machinery Based on an Incomplete Source Domain. [PDF]
Sensors (Basel), 2022 Mao G, Zhang Z, Jia S, Noman K, Li Y.
europepmc +1 more source
Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer
Molecular Oncology, EarlyView.New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau +9 more
wiley +1 more source
Domain-Invariant Partial-Least-Squares Regression
, 2018 Multivariate calibration models often fail to extrapolate beyond the calibration samples because of changes associated with the instrumental response, environmental condition, or sample matrix.
Ramin Nikzad-Langerodi (5211452) +3 more
core +1 more source
TLGP: a flexible transfer learning algorithm for gene prioritization based on heterogeneous source domain. [PDF]
BMC Bioinformatics, 2021 Wang Y +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi +2 more
wiley +1 more source