Results 151 to 160 of about 1,321,207 (310)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Domain-Based change propagation analysis: An enterprise system case study [PDF]

open access: yes, 2010
Change propagation has mainly been estimated by maintenance history or source code analysis. However, sometimes history and code are inaccessible, or impractical to analyse, such as for heterogeneous sources.
Margaret Hamilton (18029413)   +2 more
core  

Poetic journeys and other metaphors underlying literary criticism of poetry in English and Russian

open access: yesRevista Brasileira de Linguística Aplicada
The paper sets out to examine the metaphoricity of the discourse of literary criticism dealing with poetry. The research carried out in the framework of contemporary metaphor studies relying, first of all, on the Conceptual Metaphor Theory and its ...
Inesa Šeškauskienė, Oksana Valentjeva
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Fast imaging techniques of marine controlled source electromagnetic (CSEM) data [PDF]

open access: yes, 2008
Obtaining information regarding the resistivity structure of the subsurfacefrom marine CSEM data involves complex processes. 1D and 2D forward and inversemodelling are currently the standard approaches used to produce geoelectrical models,with 3D ...
Morris, Edward C.
core  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Multi-Source Domain Adaptation with Incomplete Source Label Spaces [PDF]

open access: yes
Domain adaptation is a practicable tool in real world application where there exists data scarcity. Multi-source domain adaptation attracts increasing attention due to its ability to enrich transfer knowledge by combining information from multiple ...
Zhang, G, Li, K, Zuo, H, Lu, J
core   +1 more source

Conceptual Metaphors in Narrative Advertisements for Places: A Comparative Study Between English and Lithuanian

open access: yesNalans
The paper examines 15 conceptual metaphors in advertisements for hotels based in Lithuania, focusing on the similarities and differences between English and Lithuanian versions of these advertisements.
Linas Selmistraitis   +2 more
doaj   +1 more source

Home - About - Disclaimer - Privacy