Results 141 to 150 of about 70,586 (295)
iNew Medicine, EarlyView.ABSTRACT HSPA5 (also known as GRP78/BiP) is a master regulator of the endoplasmic reticulum (ER) stress response and a key node in the proteostasis network. In neuroendocrine prostate cancer (NEPC), an aggressive, therapy‐refractory lineage that emerges under pressure from androgen receptor (AR) directed therapies, GRP78 is upregulated and co‐opted to ...
Amos Olalekan Akinyemi +14 more
wiley +1 more source
Sox2 and Sox3 are essential for development and regeneration of the zebrafish lateral line
, 2019 Cristian Alberto Undurraga
openalex +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT This study investigated the mechanism of miR‐127‐3p in tumor cell stemness and docetaxel (DTX) resistance in triple‐negative breast cancer (TNBC). hsa‐miR‐127‐3p and KIF3B levels were predicted using databases and validated in TNBC and paracancerous tissues.
Zi‐Chao He, Jun‐Jie Zhao, Ting Yan
wiley +1 more source
REST–miR-21–SOX2 axis maintains pluripotency in E14Tg2a.4 embryonic stem cells
, 2015 Sanjay K. Singh +5 more
openalex +1 more source
Signaling through BMP receptors promotes respiratory identity in the foregut via repression of Sox2 [PDF]
, 2011 Eric T. Domyan +5 more
openalex +1 more source
Emerging Therapeutic Strategies in Anti‐Aging Medicine: A Comprehensive Review
Medicine Bulletin, EarlyView.ABSTRACT Aging is orchestrated by interconnected hallmarks such as genomic instability, mitochondrial dysfunction, cellular senescence, and disrupted intercellular communication, which collectively drive chronic disease progression. Recent advances have expanded therapeutic opportunities to include pharmacological agents, gene and epigenome editing ...
Yundong Peng +8 more
wiley +1 more source
Liver Steatosis in Induced Hepatocytes From Carriers of Spinal Muscular Atrophy
Muscle &Nerve, EarlyView.ABSTRACT Introduction/Aims Although classically characterized as a motor neuron disease, spinal muscular atrophy (SMA) is increasingly recognized as a multisystem disorder. We previously showed hepatocyte‐intrinsic steatosis in SMA, raising the question of whether SMA carriers, who are typically asymptomatic, may also exhibit subclinical hepatic ...
Lingyu Sun +15 more
wiley +1 more source
Uncovering the Genetic Landscape of Spinal Dysraphism: A Retrospective Analysis of 150 Fetal Cases
Prenatal Diagnosis, EarlyView.ABSTRACT Objective Spinal dysraphism (SD) results from incomplete neural tube closure and encompasses a heterogeneous group of congenital anomalies with genetic and environmental etiologies. Although genetic contributions are recognized, causative variants remain insufficiently defined, and the clinical implications of extended genetic testing on ...
I. Bedei +9 more
wiley +1 more source