Results 161 to 170 of about 70,586 (295)

Opioids in breast cancer: Between analgesia and modulation of tumour progression

British Journal of Pharmacology, EarlyView.
Preclinical investigations consistently demonstrate that activation of μ‐opioid receptors and δ‐opioid receptors promote proliferation, migration, angiogenesis, epithelial‐mesenchymal transition, acquisition of cancer stem cell phenotypes, and chemoresistance.
Marianna Ciwun, Anna Tankiewicz‐Kwedlo, Dariusz Pawlak   +2 more
wiley   +1 more source

Utilising multi-modal data-driven network analysis to identify monotherapy and combinational therapy targets in SOX2-dependent squamous cell lung cancer. [PDF]

Commun Chem
Hwang W, Kottmann D, Guo W, MacMahon M, Correia L, Ahmed S, Harris R, McCaughan F, Han N.   +8 more
europepmc   +1 more source

Supplementary Figure 1 from Regulation of Colorectal Carcinoma Stemness, Growth, and Metastasis by an <i>miR-200c</i>-Sox2–Negative Feedback Loop Mechanism

, 2023
Yan-Xia Lu, Yuan Li, Xiaolei Xue, Min Zhou, Yan Liu, Chao Zhang, Jingping Li, Linjin Zheng, Min Hong, Xuenong Li   +9 more
openalex   +1 more source

NF‐κB Is a Potential Therapeutic Target for Histone Deacetylase Inhibitor‐Resistant Cutaneous T‐Cell Lymphoma

Cancer Science, EarlyView.
We identified a novel mechanism of resistance to histone deacetylase inhibitors (HDACi) in cutaneous T‐cell lymphoma (CTCL), mediated by NF‐κB activation. This finding highlights NF‐κB as a potential therapeutic target for overcoming HDACi resistance in CTCL.
Yuto Takahashi, Akihiro Kitadate, Sayaka Iwama, Wataru Kuroki, Ko Abe, Masahiro Yamada, Sho Ikeda, Hiroyuki Tagawa, Hideki Wakui, Masaki Hikida, Naoto Takahashi   +10 more
wiley   +1 more source

SOX2-Gen-Test [PDF]

, 2019
openaire   +1 more source

LncRNA ZFHX4-AS1 initiates an oncogenic axis involving a ZFHX4/SOX2 positive feedback loop to accelerate glioma progression. [PDF]

Front Oncol
Yan H, Wang X, Zhao Z.
europepmc   +1 more source

SOX2 regulates foregut squamous epithelial homeostasis and is lost during Barrett’s esophagus development [PDF]

Ramon U. Jin, Yuanwei Xu, T. Mamie Lih, Yang‐Zhe Huang, Toni Nittolo, Blake Sells, Olivia M. Dres, Jean S. Wang, Qing Kay Li, Hui Zhang, Jason C. Mills   +10 more
openalex   +1 more source

Supplementary Materials and Methods from Cross-talk between SOX2 and TGFβ Signaling Regulates EGFR–TKI Tolerance and Lung Cancer Dissemination

, 2023
Ming-Han Kuo, An-Chun Lee, Shih-Hsin Hsiao, Sey‐En Lin, Yu‐Fan Chiu, Lihao Yang, Chia-Cherng Yu, Shih‐Hwa Chiou, Hsien‐Neng Huang, Jen‐Chung Ko, Yu‐Ting Chou   +10 more
openalex   +1 more source

Tumor Microenvironments in Malignant Ovarian Germ Cell Tumors: MHC Class I Loss and T‐Cell Exhaustion in Dysgerminoma

Cancer Science, EarlyView.
Malignant ovarian germ cell tumor subtypes exhibit distinct tumor microenvironments. Dysgerminomas harbor abundant nonexhausted T cells, with progenitor exhausted T cells present in 60% of PD‐1–positive cases. However, MHC class I expression is lost across all analyzed subtypes, suggesting that restoring class I expression in dysgerminomas may enhance ...
Miya Nakashima, Takeshi Iwasaki, Yoshihiro Katayama, Masatoshi Shimo, Ken Takigawa, Naomi Shimada, Michiko Matsushita, Satoshi Kuwamoto, Shinya Sato, Masato Toya, Kohta Miyawaki, Koichi Akashi, Kiyoko Kato, Yoshinao Oda   +13 more
wiley   +1 more source

Ternary complexes in protein-DNA interactions: Kinetics and mechanisms. [PDF]

J Biol Chem
Hefetz A, Rogoulenko E, Levy Y.
europepmc   +1 more source