Results 161 to 170 of about 66,099 (245)

Sox2 Is Required for Maintenance and Differentiation of Bronchiolar Clara, Ciliated, and Goblet Cells

, 2009
David H. Tompkins, Valérie Besnard, Alexander W. Lange, Susan E. Wert, Angela R. Keiser, April N. Smith, Richard A. Lang, Jeffrey A. Whitsett   +7 more
openalex   +2 more sources

Patient‐Derived Cortical Organoids Reveal Senescence of Neural Progenitor Cells in Hutchinson‐Gilford Progeria Syndrome

Aging Cell, EarlyView.
HGPS patient‐derived cortical organoids exhibit progerin accumulation, nuclear abnormalities, and increased senescence in rosette structures, leading to impaired neuronal differentiation and altered gene expression. ABSTRACT Hutchinson‐Gilford progeria syndrome (HGPS) is a rare genetic disorder characterized by premature aging and primarily caused by ...
Seeun Jeon, Chul‐Sung Park, Juyoung Hong, Jieun Kim, Yun Jin Lee, Junho K. Hur, Ji Yeoun Lee   +6 more
wiley   +1 more source

Signaling through BMP receptors promotes respiratory identity in the foregut via repression of Sox2 [PDF]

, 2011
Eric T. Domyan, Elisabetta Ferretti, Kurt Throckmorton, Yuji Mishina, Silvia K. Nicolis, Xin Sun   +5 more
openalex   +1 more source

<i>SOX2</i> Variant Resulting in Hypogonadotropic Hypogonadism, Learning Difficulties, and Ear (Rather Than Eye) Anomalies. [PDF]

JCEM Case Rep
Cher WQ, Chan D.
europepmc   +1 more source

A Small-Molecule Inhibitor of Tgf-β Signaling Replaces Sox2 in Reprogramming by Inducing Nanog

, 2009
Justin K. Ichida, Joel Blanchard, Kelvin Lam, Esther Son, Julia Eunyoung Chung, Dieter Egli, Kyle M. Loh, Ava C. Carter, Francesco Paolo Di Giorgio, Kathryn Koszka, Danwei Huangfu, Hidenori Akutsu, David R. Liu, Lee L. Rubin, Kevin Eggan   +14 more
openalex   +1 more source

Craniopharyngiomas Express Embryonic Stem Cell Markers (SOX2, OCT4, KLF4, and SOX9) as Pituitary Stem Cells but Do Not Coexpress RET/GFRA3 Receptors [PDF]

, 2011
Montserrat García-Lavandeira, Carmen Sáez, Esther Díaz‐Rodriguez, Sihara Pérez-Romero, Ana Senra, Carlos Diéguez, Miguel Á. Japón, Clara V. Álvarez   +7 more
openalex   +1 more source

BRD9 inhibition as potential treatment option for testicular germ cell tumors

Andrology, EarlyView.
Abstract Background Testicular germ cell tumors (TGCT) are the predominant tumor in younger males. Usually, 5‐year survival rates are quite high, but 15–20% of patients with metastatic non‐seminomas are resistant to standard cisplatin‐based therapy.
Aylin Hansen, Christine Sanders, Florian Fronhoffs, Kai Funke, Glen Kristiansen, Hubert Schorle   +5 more
wiley   +1 more source

ADT increases prostate cancer cell invasion via altering AR/SALL4/SOX2-OCT4 stem cell signaling. [PDF]

Cell Biol Toxicol
Guo C, Kadier A, Zhang Z, Mao S, Yang B, Zheng J, Yao X.   +6 more
europepmc   +1 more source

Distinct Functions of Sox2 Control Self-Renewal and Differentiation in the Osteoblast Lineage [PDF]

, 2011
Eunjeong Seo, Upal Basu-Roy, Jiŕí Zavadil, Claudio Basilico, Alka Mansukhani   +4 more
openalex   +1 more source

Spatial transcriptomics mapping of immune cell and TGFβ signalling pathway heterogeneity in testicular germ cell tumours

Andrology, EarlyView.
Abstract Background Testicular germ cell tumours (TGCTs) are amongst the most common malignancies in young men, and their incidence is increasing worldwide. Tissue heterogeneity hampers efforts to understand how TGCT precursors (termed germ cell neoplasia in situ; GCNIS) emerge and progress, restricting elucidation of new strategies for diagnosis and ...
Sarah C. Moody, Daniela Fietz, Benedict Nathaniel, Mark Frydenberg, Ben Tran, Hans‐Christian Schuppe, Kate L. Loveland   +6 more
wiley   +1 more source