Results 141 to 150 of about 68,869 (163)

SOX2 is a positive regulator of osteoclast differentiation

Biochemical and Biophysical Research Communications, 2020
Elucidating the mechanism underlying osteoclast differentiation is important to improve our understanding of the pathophysiologies related to skeletal diseases and osteolytic metastasis in cancer. Sex-determining region Y-box containing gene 2 (SOX2), a stemness marker, is known to affect osteoblast differentiation and cancer metastasis.
Chen Shen, Jin Hong Chen, Haram Oh, Ji Hyun Park   +3 more
openaire   +2 more sources

Landscape of the SOX2 protein–protein interactome

PROTEOMICS, 2011
Abstract SOX2 is a key gene implicated in maintaining the stemness of embryonic and adult stem cells that appears to re‐activate in several human cancers including glioblastoma multiforme. Using immunoprecipitation (IP)/MS/MS, we identified 144 proteins that are putative SOX2 interacting proteins.
Xuefeng, Fang, Jae-Geun, Yoon, Lisha, Li, Yihsuan S, Tsai, Shu, Zheng, Leroy, Hood, David R, Goodlett, Gregory, Foltz, Biaoyang, Lin   +8 more
openaire   +2 more sources

Sox2: A Regulatory Factor in Tumorigenesis and Metastasis

Current Protein & Peptide Science, 2019
The transcription factor Sox2 plays an important role in various phases of embryonic development, including cell fate and differentiation. These key regulatory functions are facilitated by binding to specific DNA sequences in combination with partner proteins to exert their effects.
Sameer, Chaudhary, Zeyaul, Islam, Vijaya, Mishra, Sakshi, Rawat, Ghulam Md, Ashraf, Prasanna R, Kolatkar   +5 more
openaire   +2 more sources

SOX2 in the Skin

2016
Natacha A. Agabalyan, Andrew Hagner, Waleed Rahmani, Jeff Biernaskie   +3 more
openaire   +1 more source

SOX2 promotes dedifferentiation and imparts stem cell-like features to pancreatic cancer cells

Oncogenesis, 2013
T C Smyrk, D M Simeone, Luis Bujanda
exaly  

SOX2 has a crucial role in the lineage determination and proliferation of mesenchymal stem cells through Dickkopf-1 and c-MYC

Cell Death and Differentiation, 2011
S B Park
exaly  

Sox2

2016
openaire   +1 more source

SOX2 and cancer: current research and its implications in the clinic

Clinical and Translational Medicine, 2014
Kasia Weina, Jochen Utikal
exaly  

Mapping the Global Chromatin Connectivity Network for Sox2 Function in Neural Stem Cell Maintenance

Cell Stem Cell, 2019
Rebecca Favaro, Miriam Pagin, Chew Yee Ngan   +2 more
exaly  

SOX2, a predictor of survival in gastric cancer, inhibits cell proliferation and metastasis by regulating PTEN

Cancer Letters, 2015
Simeng Wang, Wenlan Wang, Zengshan Li
exaly