Results 141 to 150 of about 69,871 (164)

Sox2 roles in neural stem cells

The International Journal of Biochemistry & Cell Biology, 2010
Throughout vertebrate evolution, Sox2 marks the developing nervous system from its earliest developmental stages and, therein, the most undifferentiated precursor cells, including stem cells. Recent gene targeting studies investigated the function of Sox2 in two neuronal systems: the developing eye and brain.
Pevny, LH, NICOLIS, SILVIA KIRSTEN
openaire   +2 more sources

SOX2 is a positive regulator of osteoclast differentiation

Biochemical and Biophysical Research Communications, 2020
Elucidating the mechanism underlying osteoclast differentiation is important to improve our understanding of the pathophysiologies related to skeletal diseases and osteolytic metastasis in cancer. Sex-determining region Y-box containing gene 2 (SOX2), a stemness marker, is known to affect osteoblast differentiation and cancer metastasis.
Chen Shen, Jin Hong Chen, Haram Oh, Ji Hyun Park   +3 more
openaire   +2 more sources

Landscape of the SOX2 protein–protein interactome

PROTEOMICS, 2011
Abstract SOX2 is a key gene implicated in maintaining the stemness of embryonic and adult stem cells that appears to re‐activate in several human cancers including glioblastoma multiforme. Using immunoprecipitation (IP)/MS/MS, we identified 144 proteins that are putative SOX2 interacting proteins.
Xuefeng, Fang, Jae-Geun, Yoon, Lisha, Li, Yihsuan S, Tsai, Shu, Zheng, Leroy, Hood, David R, Goodlett, Gregory, Foltz, Biaoyang, Lin   +8 more
openaire   +2 more sources

Sox2: A Regulatory Factor in Tumorigenesis and Metastasis

Current Protein & Peptide Science, 2019
The transcription factor Sox2 plays an important role in various phases of embryonic development, including cell fate and differentiation. These key regulatory functions are facilitated by binding to specific DNA sequences in combination with partner proteins to exert their effects.
Sameer, Chaudhary, Zeyaul, Islam, Vijaya, Mishra, Sakshi, Rawat, Ghulam Md, Ashraf, Prasanna R, Kolatkar   +5 more
openaire   +2 more sources

SOX2 in the Skin

2016
Natacha A. Agabalyan, Andrew Hagner, Waleed Rahmani, Jeff Biernaskie   +3 more
openaire   +1 more source

The Role of SOX2-Interacting Proteins in Gene Regulation by SOX2

2016
openaire   +1 more source

SOX2 promotes dedifferentiation and imparts stem cell-like features to pancreatic cancer cells

Oncogenesis, 2013
Luis Bujanda, T C Smyrk, Bujanda L
exaly  

Sox2

2016
openaire   +1 more source

SOX2 has a crucial role in the lineage determination and proliferation of mesenchymal stem cells through Dickkopf-1 and c-MYC

Cell Death and Differentiation, 2011
Kang S K, S B Park
exaly  

SOX2 and cancer: current research and its implications in the clinic

Clinical and Translational Medicine, 2014
Jochen Utikal
exaly