Results 121 to 130 of about 212,746 (311)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

PERBANDINGAN SUSU SKIM DENGAN TEPUNG KEDELAI DAN KONSENTRASI COCOA BUTTER SUBSTITUTE TERHADAP KARAKTERISTIK WHITE CHOCOLATE [PDF]

, 2017
The purpose of this research was to determine the characteristics of white chocolate influenced by the ratio of skim milk with the addition of soy powder and cocoa butter substitute (CBS). This research consists of preliminary and main research. The
WILLY PRANATA WIDJAJA, DS, Yusep Ikrawan, DS, YUSRA SASKIA NABILA, 123020127   +2 more
core  

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Kadar Protein Dan Sifat Organoleptik Es Krim Tape Sukun Dengan Penambahan Sari Kacang Kedelai Dan Ubi Ungu Sebagai Pewarna Alami [PDF]

, 2015
Ice cream is a solid food made from milk combined with flavorings, sweeteners and other frozen foods. In this study the manufacture of ice cream using a mixture of cow’s milk, soy bean extract, tape breadfruit and purple potato extract.
, Dra. Aminah Asngad, M.Si, SAFITRI, Ita
core  

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Development and evaluation of an alternative protein-rich legume-based snack

Heliyon
The aim of this research is to develop a novel protein-rich potato snack for health-conscious individuals seeking a nutritious protein snack. A blend of raw materials including potato flakes, corn starch, sugar, and lecithin is combined with various ...
Dima Mnayer, Karine Joubrane
doaj   +1 more source

OILSEED PROTEINS - PRESENT UTILIZATION PATTERNS [PDF]

Emphasizes the importance of soybeans as a source of protein in the human diet. Provides examples of soy-protein products on the market today and speculates as to their future.Food Consumption/Nutrition/Food Safety,
Wilding, M. Dean
core   +1 more source

Sifat Prooksidatif Fortifikan NaFeEDTA Dan Fe-SULFAT Pada Kecap Hasil Fortifikasi [PDF]

, 2009
Iron in iron-fortified soy sauce may have oxidative effect in both oil and amino acids or protein component. In order to evaluate the possible oxidative properties of both NaFeEDTA and FeSO fortificants, a study of oxidation in soy sauce fortified with ...
Astuti, M. (Mary), Marsono, Y. (Yustinus), Naruki, S. (Sri), Raharjo, S. (Sri)   +3 more
core