Results 101 to 110 of about 62,070 (311)

Phytoestrogens [PDF]

, 2004
Collectively, plants contain several different families of natural products among which are compounds with weak estrogenic or antiestrogenic activity toward mammals.
Adlercreutz H, Alekel DL, Bhathena SJ, Bielenberg J, Biendl M, Boller B, Dai Q, Day JK, de Kleijn MJJ, den Tonkelaar I, denTonkelaar I, Dewick PM, Ebisawa H, Fritz WA, Guo TL, Hodgson JM, Horn-Ross PL, ILDIS, Kim CS, Lamartiniere CA, Maggiolini M, Maskarinec G, McCann SE, Mentor MR, MerzDemlow BE, Newbold RR, Pan W, Peluso MR, Richard A. Dixon, Seested S, Setchell KDR, Setchell KDR, Setchell KDR, Slavin JL, Stevens JF, Whitten PL, Yanagihara K, Zhang Y   +37 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Physicochemical and sensory properties of novel cookies enriched with soy and anchovy protein isolate (Stolephorus insularis)

Applied Food Research
Novel formula cookies are needed to meet nutritional requirements in the community and prevent diseases related to diet. This study aimed to evaluate the physicochemical and sensory properties of cookies enriched with a combination of proteins from soy ...
Meda Canti, Maximilliam Febriand Putra, Rory Anthony Hutagalung, Anastasia Tatik Hartanti, Florence Della   +4 more
doaj   +1 more source

Dietary soy and meat proteins induce distinct physiological and gene expression changes in rats [PDF]

, 2016
This study reports on a comprehensive comparison of the effects of soy and meat proteins given at the recommended level on physiological markers of metabolic syndrome and the hepatic transcriptome.
A Hagiwara, A Lass, A Shukla, A Subramanian, AM Uhe, B He, BB Albert, C Brandsch, C Chaveroux, CJ Andersen, CW Law, D Eberle, D El Khoury, D Gaidatzis, D Karolchik, D Merico, D Ord, D Tome, DW Gietzen, E Tornberg, G Fromentin, G Sarwar, H Sidransky, HX Yuan, J Cacho, J Schwarz, JI Lee, JL Jewell, JM Beasley, KK Carroll, L Abatangelo, L Noriega-Lopez, LE Matarese, M Friedman, M Shimobayashi, MD Robinson, MD Robinson, ME Ritchie, ML Orgeron, MS Kilberg, N Tachibana, PG Reeves, PM Leung, PM Pereira, R Bourgon, R Hoffenberg, R Hosomi, S Guo, S Madani, S Wen, SM Potter, SN Twigger, T Berry, TG Anthony, V Ranawana, W Gade, W Kang, Y Takahashi   +57 more
core   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Whey proteins interact with lipids during autoxidation primarly via the production of reactive carbonyl species [PDF]

, 2010
Nowadays, it is well recognized that polyunsaturated fatty acids (PUFAs) can provide extensive nutritional and health benefits. Thus, ω-3 PUFAs have been considered to contribute to the prevention of several diseases.
Cucu, Tatiana, De Meulenaer, Bruno, Devreese, Bart, Kerkaert, Barbara, Mestdagh, Frédéric   +4 more
core   +1 more source

Rheological characterization of the thermal gelation of cowpea protein isolates: Effect of pretreatments with high hydrostatic pressure or calcium addition [PDF]

, 2019
Pretreatments with high hydrostatic pressure (HHP) or calcium addition were assessed for thermal gelation of two cowpea protein isolates (protein extraction at pHs 8.0, standard (A8) or 10.0, pH-shifting-modified (A10).
Avanza, María Victoria, de Llamballerie, Marie, Peyrano, Felicitas, Speroni Aguirre, Francisco José   +3 more
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Identification of a highly transmissible animal-independent Staphylococcus aureus ST398 clone with distinct genomic and cell adhesion properties. [PDF]

, 2012
A methicillin-resistant Staphylococcus aureus (MRSA) clone known as ST398 has emerged as a major cause of acute infections in individuals who have close contact with livestock.
Alikhan, Armand-Lefevre, Bens, Bhat, Bootsma, Castillo-Ramirez, Crombe, Cuny, DelVecchio, Devriese, Fan, Graveland, Hasman, Herron-Olson, Kaneko, Kapatral, Khanna, Leonard, Lowder, Lowy, McCarthy, McCarthy, Phillips, Rasigade, Rocha, Schijffelen, Stegger, Sung, Tatusov, Uhlemann, Uhlemann, van Belkum, van Cleef, van Loo, van Wamel, Viana, Voss, Walsh, Wassenberg, Witte   +39 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source