Results 251 to 260 of about 2,250,967 (273)

The major glycolipid recognized by SP-D in surfactant is phosphatidylinositol

Biochemistry, 1992
Surfactant protein D (SP-D), a multimeric calcium-dependent lectin isolated from pulmonary alveolar lavage, has been previously shown to interact reversibly with crude surfactant [Persson et al. (1990) J. Biol. Chem. 265, 5755-5760]. In this study, SP-D is shown to interact reversibly with a preparation of organelles enriched in lamellar bodies, in a ...
A V, Persson, B J, Gibbons, J D, Shoemaker, M A, Moxley, W J, Longmore   +4 more
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Surfactant Proteins and SP-D

American Journal of Respiratory Cell and Molecular Biology, 1991
.The lipid and protein components of surfactant are syn­ thesized and secreted by the alveolar type II epithelial cell. Newly secreted surfactant adsorbs to the alveolar air-liquid interface, where it spreads as a monomolecular film that serves to reduce surface tension during expiration.
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Serum SP-D is a marker of lung injury in rats

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2002
Pulmonary surfactant protein D (SP-D) is expressed in alveolar type II and bronchiolar epithelial cells and is secreted into alveoli and conducting airways. However, SP-D has also been measured in serum and is increased in patients with acute respiratory distress syndrome, pulmonary fibrosis, and alveolar proteinosis.
Tianli, Pan, Larry D, Nielsen, Martin J, Allen, Kathleen M, Shannon, John M, Shannon, Moises, Selman, Robert J, Mason   +6 more
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SP-D as a biomarker for COPD in the Lebanese population

European Respiratory Journal, 2014
Background : Surfactant protein D (SP-D), a promising systemic biomarker of chronic obstructive pulmonary disease (COPD) was never evaluated in the Lebanese population. Objective : The validity of serum SP-D as a biomarker for COPD, in
Akiki, Zeina, Fakih, Dalia, Jounblat, Rania, Chamat, Souleima, Waked, Mirna, Sørensen, Grith Lykke, Nadif, Rachel, Salameh, Pascale   +7 more
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Developmental Expression of Pulmonary Surfactant Protein D (SP-D)

American Journal of Respiratory Cell and Molecular Biology, 1991
Abstract Surfactant protein D (SP-D) is a collagenous, surfactant-associated, carbohydrate-binding protein that is synthesized by pulmonary epithelial cells. In the present studies, we examined the expression of SP-D and SP-D mRNA during late fetal (day 17, 19, 21) and early postnatal (day 5) rat lung development using immunochemical,
E, Crouch, K, Rust, W, Marienchek, D, Parghi, D, Chang, A, Persson   +5 more
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Binding specificity of lung surfactant protein SP-D for glucosylceramide

Biochemical and Biophysical Research Communications, 1992
The specificities of the binding of lung surfactant protein SP-D to glycolipids were examined using 125I-labeled SP-D as a probe. When the binding study was performed on TLC plates, SP-D bound exclusively to GlcCer, whereas it failed to bind to GalCer, GM1, GM2, asialo-GM1, asialo-GM2, sulfatide, Forssman antigen, ceramide dihexoside, ceramide ...
Y, Kuroki, S, Gasa, Y, Ogasawara, M, Shiratori, A, Makita, T, Akino   +5 more
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Surfactant Protein D (SP‐D) and Systemic Scleroderma (SSc)

The Journal of Dermatology, 2001
AbstractWe measured serum levels of SP‐D in collagen diseases (110 cases) such as systemic scleroderma (SSc), scleroderma spectrum disorders (SSD), systemic lupus erythematodes (SLE), Sjögren syndrome (Sjs), dermatomyositis (DM), rheumatoid arthritis (RA), and dermatitis (DE) (109 cases) as a control.
M, Maeda, Y, Ichiki, Y, Aoyama, Y, Kitajima   +3 more
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Ontogeny of surfactant apoprotein D, SP-D, in the rat lung

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1991
Surfactant protein D (SP-D) is a collagenous surfactant-associated glycoprotein synthesized by alveolar type II cells. Antiserum against rat SP-D was raised in rabbits and an enzyme-linked immunosorbant assay (ELISA) has been developed using anti-rat SP-D IgG.
Y, Ogasawara, Y, Kuroki, M, Shiratori, H, Shimizu, K, Miyamura, T, Akino   +5 more
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Linking surfactant protein SP-D and IL-13: Implications in asthma and allergy

Molecular Immunology, 2013
Surfactant protein D (SP-D) is an innate immune molecule that plays a protective role against lung infection, allergy, asthma and inflammation. In vivo experiments with murine models have shown that SP-D can protect against allergic challenge via a range of mechanisms including inhibition of allergen-IgE interaction, histamine release by sensitised ...
Qaseem, Asif S, Sonar, Sanchaita, Mahajan, Lakshna, Madan, Taruna, Sorensen, Grith L, Shamji, Mohamed H, Kishore, Uday   +6 more
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Surfactant Proteins SP-A and SP-D as Modulators of the Allergic Inflammation in Asthma

Pathobiology, 2002
Surfactant proteins A and D (SP-A and SP-D) are members of the collectin family and bind to various motifs of microorganisms, particles and allergens. They play an important role in the first-line defense within the lung. Recent research has highlighted that these proteins not only augment innate immune responses to invading microorganisms but also act
J M, Hohlfeld, V J, Erpenbeck, N, Krug
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