Results 41 to 50 of about 272,474 (290)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Planning and maintaining Nature Based Solutions : Lessons for foresight and sustainable care from Berlin, Jakarta, Melbourne and Santiago de Chile [PDF]
, 2023 Nature-based solutions (NBS) in cities offer significant ecological benefits but face challenges in planning, maintenance, and equitable distribution. This chapter explores how urban green spaces and trees can be preserved or restored and examines how ...
Giannotti, Emanuel +7 more
core +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
The morphological impact of municipal planning instruments on urban agriculture
Cidades, Comunidades e Território, 2020 With the growth of urban population, humanity faces new challenges concerning urban food provision. Urban planning is paramount to guarantee a sustainable functioning of the several systems which operate within the urban realm, including the food system.
Ana Mélice Dias, Teresa Marat-Mendes
doaj
Redai dili, 2021 Unlike previous ecological restoration programs, the main focus of ecological restoration of national land space has changed from a single element in the natural ecology to the whole social-ecological system.
Ye Yuyao +6 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Smart Cities, 2023 The conventional approach to urban planning has predominantly focused on horizontal dimensions, disregarding the potential risks originating from outer space.
Ulpia-Elena Botezatu +3 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Changes in Green Space Intensity in Budapest’s 14th district
4D, 2023 This research used the ”Green Space Intensity” (GSI) index to describe the changes in green space within Zugló, Budapest’s 14th district, from 1992 to 2020.
Sándor Jombach +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source