Results 51 to 60 of about 272,474 (290)

On the benefit of ∈-efficient solutions in multi objective space mission design [PDF]

open access: yes, 2008
In this work we consider multi-objective space mission design problems. We will show that it makes sense from the practical point of view to consider in addition to the (Pareto) optimal solutions also nearly optimal ones since this increases ...
Vasile, M.   +2 more
core  

Travel Plans in Public Transit Networks Using Artificial Intelligence Planning Models

open access: yesApplied Artificial Intelligence, 2019
Users of public transit networks require tools that generate travel plans to traverse them. The main issue is that public transit networks are time and space dependent.
Fernando Elizalde-Ramírez   +3 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Engineering surveys as the basis of the geo-ecological risk management in the urban underground construction

open access: yesИзвестия высших учебных заведений: Геология и разведка, 2016
Currently an ecological basis of the urban planning documentation is performed during engineering and environmental surveys, which in the development of urban underground space should ensure the optimality of design decisions on environmental ...
E. Yu. Kulikova
doaj   +2 more sources

Spatial Planning as a Tool for Sustainable Development. Polish Realities

open access: yesBarometr Regionalny, 2017
Sustainable development is currently the basic philosophy of shaping socio-economic development. It seeks to ensure that the improvement of living conditions and development of the economy are reconciled and the proper conditions for the functioning of ...
Waldemar Gorzym-Wilkowski
doaj   +1 more source

Principles of the organization of space-planning solutions for nuclear medicine facilities

open access: yesConstruction materials and products
It is nearly impossible to imagine modern medicine without the use of nuclear technologies, the introduction of which has led to the emergence of new methods of prevention, diagnosis and treatment of various diseases, as well as reduced mortality rates among patients and improved the quality of life of patients with diseases in the field of oncology ...
Yu.I. Lempl, A.E. Balakina
openaire   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

An architecture for autonomic web service process planning [PDF]

open access: yes, 2008
Web service composition is a technology that has received considerable attention in the last number of years. Languages and tools to aid in the process of creating composite web services have been received specific attention.
Moore, Colm   +3 more
core  

Strategic Environmental Assessment as a Support in a Sustainable National Waste Management Program—European Experience in Serbia

open access: yesEnergies, 2022
Strategic Environmental Assessment (SEA) is one of the most important instruments for directing the strategic planning process toward the sustainable development goals in various areas of human activity. This also applies to the field of waste management.
Boško Josimović   +2 more
doaj   +1 more source

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