Results 61 to 70 of about 272,474 (290)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Urban Underground Space Planning Idea and Path Based on a “Dual-Use” Concept [PDF]

中国工程科学
As global climate change and urbanization processes accelerate, the risks of compound disasters have significantly increased, rendering traditional disaster prevention facilities inadequate for meeting emergency demands under extreme scenarios. The “dual-
Wei Wang, Junyi Zhu, Guosheng Wang, Xiaodong Guo, Yuan Jiang, Dechun Lu   +5 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Generating Geodesic Flows and Supergravity Solutions [PDF]

, 2009
We consider the geodesic motion on the symmetric moduli spaces that arise after timelike and spacellike reductions of supergravity theories. The geodesics correspond to timelike respectively spacelike p-brane Solutions when they are lifted over a p ...
Trigiante, Mario, Van Riet, T., Riet, T. Van,, Bergshoeff, E., Bergshoeff, E.,, Ploegh, A.,, Trigiante, M.,, Trigiante, M., Chemissany, W., Chemissany, W.,, Ploegh, A.   +10 more
core   +1 more source

Techniques of shaping spiritual education centers: vertical unification of volumes

Архитектон
The article contains an analysis of factors influencing the choice of vertical unification of volumes as the main technique of a cathedral complex, identifying the relationships between composition, functional content and space-planning solutions of ...
Elena V. Barantseva
doaj   +1 more source

Tabu search applied to transmission system expansion planning considering de-planning

Revista Facultad de Ingeniería Universidad de Antioquia, 2013
This paper presents two mathematical models and one methodology for the long-term transmission system expansion planning problem considering de-planning. Traditionally this problem is solved searching the lowest cost investment plan for one given period.
Antonio Escobar, Ramón Gallego , Eliana Toro   +2 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Sustainability, Conservation and Ecology in Spatial Planning and Design: New approaches, solutions, applications

, 2023
With climate change, differences have emerged in spatial planning and designs in urban and rural areas. Considering our present and future conditions, professions dealing with spatial planning and design will have great responsibilities. Rethinking urban
Özyavuz, Murat
core   +1 more source