Results 71 to 80 of about 6,366,300 (284)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
, 2014 Wheeler emphasized the study of Superspace - the space of 3-geometries on a spatial manifold of fixed topology. This is a configuration space for GR; knowledge of configuration spaces is useful as regards dynamics and QM.In this Article I consider furthmore generalized configuration spaces to all levels within the conventional `equipped sets' paradigm ...
openaire +2 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
, 2005 Pamphlet accompanying an exhibition held at Canberra Contemporary Art Space, A.C.T., 7 May - 4 June 2005.Essayist: Adam ...
Canberra Contemporary Art Space
core
Thinking, Longing, and Nearness: In Memoriam Bernd Jager (1931–2015)
Phenomenology & Practice, 2016 See full-text article.
David Seamon
doaj +1 more source
Dual spaces of weighted spaces [PDF]
Transactions of the American Mathematical Society, 1970 The topological duals of a large class of weighted spaces of continuous functions are characterized as spaces of Radon measures which can be factored into a product of a weight function and a bounded Radon measure. We next obtain a representation for a base for the equicontinuous subsets of these dual spaces and for the extremal points of the members ...
openaire +2 more sources
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
The Structure of Space and Problems of Our Time
Проект БайкалSince antiquity the image of space as emptiness has been opposed to the image of material space filled with some essence. For a long time this role was played by the theories of ether.
Светлана Головня +1 more
doaj +1 more source