Results 51 to 60 of about 12,429,422 (276)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
, 1973 A pressure suit for high altitude flights, particularly space missions is reported. The suit is designed for astronauts in the Apollo space program and may be worn both inside and outside a space vehicle, as well as on the lunar surface.
Bessette, R. J. +7 more
core +1 more source
The space of intervals in a Euclidean space
, 2005 For a path-connected space X, a well-known theorem of Segal, May and Milgram asserts that the configuration space of finite points in R^n with labels in X is weakly homotopy equivalent to the n-th loop-suspension of X. In this paper, we introduce a space
May +3 more
core +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Studies in History and Philosophy of Science Part B: Studies in History and Philosophy of Modern Physics, 2017 This paper investigates the significance of T-duality in string theory: the indistinguisha- bility with respect to all observables, of models attributing radically different radii to space – larger than the observable universe, or far smaller than the Planck length, say. Two interpretational branch points are identified and discussed.
openaire +1 more source
Knowledge spaces and learning spaces [PDF]
, 1920 How to design automated procedures which (i) accurately assess the knowledge of a student, and (ii) efficiently provide advices for further study? To produce well-founded answers, Knowledge Space Theory relies on a combinatorial viewpoint on the assessment of knowledge, and thus departs from common, numerical evaluation.
Doignon, Jean-Paul +1 more
openaire +4 more sources
, 2013 The Tavistock’s Thinking Space aims to bring issues of diversity from a hidden, subconscious or unconscious place to one that is more open, conscious and ...
Lowe, Frank
core
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source