Results 61 to 70 of about 6,366,300 (284)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Проект БайкалA thing, being placed in space, like in aitch-two-oh, despising the risk, longs to displace the space; but your eye does not notice the splashes of space on the floor. J. Brodsky.
Елена Григорьева
doaj +1 more source
Universal design in housing for people with disabilities: A review [PDF]
Journal of Design and the Built Environment, 2015 Housing standard for disabled people is a new dimension in quality of life. To the disabled people who are housebound, the house is the central focus of their existence.
Siti Kalkhalah Shahrom +1 more
doaj
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
An Educational Introduction to ITAR and EAR Regarding Pressure Suits and Space Suits
Immediate accessThis item is made available by the University of Arizona Center for Human Space Exploration (CHaSE) with support from the University of Arizona Libraries.
Tresch, Trent
core +4 more sources
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Journal of Asian Architecture and Building Engineering, 2018 In reality, an open space comprises various spatial elements, and people choose a place for sojourn according to the attraction created by the spatial elements.
Mingyeh Hsieh, Yingchu Chen, Wenyen Lee
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Test Spaces for Normal Spaces [PDF]
Proceedings of the American Mathematical Society, 1962 Let Q be a class of topological spaces. For X in Q, let dim X denote the dimension of X defined in terms of finite open coverings. If Q is the class of all normal spaces, then the dimension of spaces X in Q is characterized by the following theorem [2, p. 212]: dimX^n if, and only if, given any closed subset C of X, any continuous mapping of C into the
openaire +2 more sources