Results 111 to 120 of about 3,403,920 (315)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Medical operations and life sciences activities on space station [PDF]
Space station health maintenance facilities, habitability, personnel, and research in the medical sciences and in biology are discussed. It is assumed that the space station structure will consist of several modules, each being consistent with Orbiter ...
Johnson, P. C., Mason, J. A.
core +1 more source
Comparing Human Activity Density and Green Space Supply Using the Baidu Heat Map in Zhengzhou, China [PDF]
, 2020 Shumei Zhang +6 more
openalex +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Prospects and limitations for use of frequency spectrum from 40 to 300 GHz [PDF]
The existing and future use of the electromagnetic spectrum from 40 to 300 gigahertz is discussed. The activities envisioned for this segment of the electromagnetic spectrum fall generically into two basic categories: communications and remote sensing ...
Catoe, C. E.
core +1 more source
LEGAL REGULATION OF THE INTERNET: MAJOR SPACES AND DIRECTIONS OF ACTIVITY OF THE STATE
, 2020 Alina S. Anisimova
openalex +1 more source
Is level of neighbourhood green space associated with physical activity in green space? [PDF]
, 2013 Katherine L. Ord +2 more
openalex +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source