Results 111 to 120 of about 3,422,349 (365)

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

Continuous space representations of human activity spaces

open access: yes, 2005
Arbeitsberichte Verkehrs- und Raumplanung ...
Vaze, Vikrant S.   +2 more
openaire   +2 more sources

Medical operations and life sciences activities on space station [PDF]

open access: yes
Space station health maintenance facilities, habitability, personnel, and research in the medical sciences and in biology are discussed. It is assumed that the space station structure will consist of several modules, each being consistent with Orbiter ...
Johnson, P. C., Mason, J. A.
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

Spaces seeking activities - activities seeking spaces: Evaluation and policy design of neighbourhood-wide urban community spaces

open access: yesCity, Culture and Society
Cities thrive on the vibrant interplay of community-driven initiatives and the adaptive reuse of public spaces that foster socio-cultural activities, enriching civic life. However, these grassroots efforts often confront challenges such as spatial inadequacies caused by bureaucratic zoning policies and the scarcity of affordable real estate.
Blečić, Ivan   +3 more
openaire   +2 more sources

Aeronautics and space report of the President, 1980 activities [PDF]

open access: yes
The year's achievements in the areas of communication, Earth resources, environment, space sciences, transportation, and space energy are summarized and current and planned activities in these areas at the various departments and agencies of the Federal ...

core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

News of Brazilian space activities [PDF]

open access: yes
Remote sensing and meteorological observations of satellites are covered. Development of an oceanographic atlas, prediction of droughts, and results of geological surveys using satellite data are ...

core   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

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