Results 71 to 80 of about 3,422,349 (365)
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
Administrative Legal Support of Outer Space Activities of the Federative Republic of Brazil [PDF]
Advanced Space Law, 2019 The Federative Republic of Brazil is a progressive country that meets international standards of space law, has the necessary natural conditions for space exploration (lies near the equator and around the ocean) and seeks to develop international ...
Roman Mkrtchian +2 more
doaj +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
The need for a legal framework for space activities in Colombia [PDF]
Civilizar, 2011 The importance of education and dissemination of the outer space law, as a matter to be included in the programs of the law faculties or schools in Colombia, must be a present commitment.
Julieta Arenas Ceballos
doaj
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
FINANCIAL SECURITY OF THE DEVELOPMENT NEW ECONOMY
Мир новой экономики, 2018 The article is devoted to the financial support of the development of the new economy (on the example of space activities). The author shows that space activities relate to a very promising area of economic activity, they are a powerful generator of ...
VLADIMIR GAVRILOVICH Starovoytov
doaj
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Administrative-Legal Regulation of Ukraine’s Space Activities: Challenges in Wartime and Strategic Perspectives [PDF]
Advanced Space LawThis article examines the administrative and legal mechanisms for coordinating Ukraine’s space activities during martial law and post-war recovery. Particular attention is paid to the impact of large-scale armed aggression on the development of the space
Inesa Kostenko
doaj +1 more source
Planning activities in space [PDF]
Three aspects of planning activities in space are presented. These include generating plans efficiently, coordinating actions among multiple agents, and recovering from plan execution errors.
Chang, Kai-Hsiung
core +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source