Results 101 to 110 of about 4,057,470 (304)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Mathematical expressions of the drag-based models for predicting the arrival time of coronal mass ejection and their development and evolutionary processes

Frontiers in Astronomy and Space Sciences
As one of the most violent solar activities, coronal mass ejections (CMEs) are eruptions of the large-scale magnetized plasma from the Sun’s upper atmosphere into interplanetary space.
Xinhua Zhao, Chenyu Shi, Chenyu Shi, Chenyu Shi, Xiao Liu, Xueshang Feng, Xueshang Feng, Yufen Zhou, Nanbin Xiang, Nanbin Xiang, Linhua Deng, Alexey Kuznetsov, Christian Möstl   +12 more
doaj   +1 more source

Spaces seeking activities - activities seeking spaces: Evaluation and policy design of neighbourhood-wide urban community spaces

City, Culture and Society
Cities thrive on the vibrant interplay of community-driven initiatives and the adaptive reuse of public spaces that foster socio-cultural activities, enriching civic life. However, these grassroots efforts often confront challenges such as spatial inadequacies caused by bureaucratic zoning policies and the scarcity of affordable real estate.
Blečić, Ivan, Cois, Ester, Muroni, Emanuel, Saiu, Valeria   +3 more
openaire   +2 more sources

SOLAR ERUPTION ON 4 JANUARY 2011: CASE STUDY FOR SPACE EARLY WARNING [PDF]

, 2011
We perform intuitive analysis for solar eruption on 4 January 2011. Since we do not have magnetic observational data from the eruption, we perform first order calculation and expands it as interplanetary total effect of energy propagation by retro ...
Bambang, Setiahadi
core  

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Comparative Study of the Single‐Event Functional Interrupt (SEFI) Rate in Solid‐State Drives (SSD) Through Ground and On‐Orbit Testing

Space Weather
Space radiation poses a significant threat to the reliability of spacecraft equipment, while traditional static space environment models exhibit substantial inaccuracies in calculating on‐orbit error rates. This study investigates single‐event functional
Yingqi Ma, Tian Yu, Xiaoheng Xu, Peng Guo, Chunqin Wang, Guohong Shen, Zhikang Fu, Longlong Zhang, Jieyi Wang, Bo Yang, Yunziwei Deng, Qiang Li, Long Zhang   +12 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

The Evolution of Hot Flow Anomalies in Martian Space Environment

Geophysical Research Letters
Hot Flow Anomalies (HFAs) are transient foreshock structures generated by solar wind discontinuity‐bow shock interactions, with their evolution only confirmed near Earth.
Heying Wang, Mingyu Wu, Yangjun Chen, Qi Lv, Guoqiang Wang, Sudong Xiao, Peng E, Aimin Du, Ding Yuan, Tielong Zhang   +9 more
doaj   +1 more source

Scheduling Markovian PERT networks with maximum-NPV objective. [PDF]

We examine project scheduling with net-present-value objective and exponential activity durations, using a continuous-time Markov decision chain. Based on a judicious partitioning of the state space, we achieve a significant performance improvement ...
Creemers, Stefan, Lambrecht, Marc, Leus, Roel   +2 more
core