Results 111 to 120 of about 10,477,825 (292)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Jefferson County Open Space Master Plan

, 2022
COMMUNITY RESOURCES - OPEN SPACE - ADOPTION OF THE JEFFERSON COUNTY OPEN SPACE MASTER PLAN Approval of the Open Space Five Year Master Plan by the Board of County Commissioners.
Jefferson County Open Space (Program);
core  

Spectrophotometric properties of Martian soil at the landing area of the Tianwen–1 Zhurong rover

Astronomy & Astrophysics
Context. The Navigation and Terrain Camera (NaTeCam) on board the Zhurong rover acquired extensive imaging data of the landing site under a wide range of phase angles, providing a unique opportunity to investigate the photometric properties of this area.
Zhou Xiang, Yang Yazhou, Wu Xing, Liu Yang, Wan Wenhui, Liu Bin, Liu Jia, Zou Yongliao   +7 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

The disrupted jet stream and its influence on flight time during solar proton events

Scientific Reports
The long-chain effects of eruptive solar activities on Earth’s magnetosphere, ionosphere, and the mid-to-lower atmospheric circulation are an important theoretical research topic in the fields of space weather and atmospheric science.
Xiaoheng Xu, Yi Wang, Fengsi Wei, Xueshang Feng, Manhui Bo, Hongwu Tang, Diansheng Wang, Lei Bian, Boyi Wang, Pingbing Zuo, Chaowei Jiang, Xiaojun Xu, Zilu Zhou, Zeng Li, Peng Zou, Yun Li, Liang Zeng, Xiaoxing Zhu   +17 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Comparative Study of the Single‐Event Functional Interrupt (SEFI) Rate in Solid‐State Drives (SSD) Through Ground and On‐Orbit Testing

Space Weather
Space radiation poses a significant threat to the reliability of spacecraft equipment, while traditional static space environment models exhibit substantial inaccuracies in calculating on‐orbit error rates. This study investigates single‐event functional
Yingqi Ma, Tian Yu, Xiaoheng Xu, Peng Guo, Chunqin Wang, Guohong Shen, Zhikang Fu, Longlong Zhang, Jieyi Wang, Bo Yang, Yunziwei Deng, Qiang Li, Long Zhang   +12 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Piantanida Near Space Balloon Gondola Engineered Drawing and Details

Immediate accessThis item is made available by the University of Arizona Center for Human Space Exploration (CHaSE) with support from the University of Arizona Libraries.
Tresch, Trent
core   +3 more sources