Results 91 to 100 of about 4,057,470 (304)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Review of recent observations of magnetic holes in the solar wind

Discover Space
Magnetic holes (MHs) are ubiquitous coherent structures within the solar wind, defined by localized depressions in the magnetic field. They are increasingly recognized as fundamental sites of energy conversion and particle energization, playing a crucial
C. Y. Li, Y. Wang, F. S. Wei, X. S. Feng, Z. K. Xu, Y. X. Lu, B. Y. Wang, P. B. Zuo, C. W. Jiang, X. J. Xu, Z. L. Zhou   +10 more
doaj   +1 more source

Spectrophotometric properties of Martian soil at the landing area of the Tianwen–1 Zhurong rover

Astronomy & Astrophysics
Context. The Navigation and Terrain Camera (NaTeCam) on board the Zhurong rover acquired extensive imaging data of the landing site under a wide range of phase angles, providing a unique opportunity to investigate the photometric properties of this area.
Zhou Xiang, Yang Yazhou, Wu Xing, Liu Yang, Wan Wenhui, Liu Bin, Liu Jia, Zou Yongliao   +7 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

The disrupted jet stream and its influence on flight time during solar proton events

Scientific Reports
The long-chain effects of eruptive solar activities on Earth’s magnetosphere, ionosphere, and the mid-to-lower atmospheric circulation are an important theoretical research topic in the fields of space weather and atmospheric science.
Xiaoheng Xu, Yi Wang, Fengsi Wei, Xueshang Feng, Manhui Bo, Hongwu Tang, Diansheng Wang, Lei Bian, Boyi Wang, Pingbing Zuo, Chaowei Jiang, Xiaojun Xu, Zilu Zhou, Zeng Li, Peng Zou, Yun Li, Liang Zeng, Xiaoxing Zhu   +17 more
doaj   +1 more source

Continuous space representations of human activity spaces

, 2005
Arbeitsberichte Verkehrs- und Raumplanung ...
Vaze, Vikrant S., Schönfelder, Stefan, Axhausen, Kay W.; id_orcid0000-0003-3331-1318   +2 more
openaire   +2 more sources

From Economic Activity to Understanding Spaces [PDF]

This paper constructs the probability space underlying the random variable of any time dependent econometric specification. The construction links concrete economic activity, both perceived and recorded, and econometric formulations.
Diego Iribarren
core  

Amazing Space: Cat's Eye Nebula (NGC 6543) Lithograph [PDF]

, 2005
This lithograph features Hubble Space Telescope images and includes text that describes and explains the images. There is also an accompanying inquiry-based classroom activity entitled “In Search of the Complex Structures of Planetary Nebulae.” This ...
Bonnie Eisenhamer
core